产品说明书
Magnolol
 |
同义名 : | NSC 293099 |
| CAS号 : | 528-43-8 | |
| 货号 : | A326464 | |
| 分子式 : | C18H18O2 | |
| 纯度 : | 98% | |
| 分子量 : | 266.334 | |
| MDL号 : | MFCD00016658 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(394.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
IP 2% DMSO+2% Tween80+30% PEG300+water 6 mg/mL clear PO 0.5% CMC-Na 42 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Magnolol(5, 10 and 15 mg/kg) significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity[3].Moreover, magnolol could effectively improve the carcass and meat quality of Linwu ducks by regulating the antioxidant status and would be a potential candidate to replace antibiotic[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00966953 | - | Completed | - | - | |
| NCT02310308 | Dental Caries | Not Applicable | Unknown | November 2015 | Italy ... 展开 >> Department of Surgery, Microsurgery and Medicine Sciences University of Sassari Sassari, Sardinia, Italy, I-07100 WHO CC University of Milan Milan, Italy, I-20121 收起 << |
| NCT00966953 | Gingival Diseases | Phase 3 | Completed | - | United States, New York ... 展开 >> Eastman Dental Center - University of Rochester Rochester, New York, United States, 14642-8315 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.75mL 0.75mL 0.38mL |
18.77mL 3.75mL 1.88mL |
37.55mL 7.51mL 3.75mL |
| 参考文献 |
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