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FAUC 213

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Chemical Structure| 337972-47-1 同义名 : -
CAS号 : 337972-47-1
货号 : A1249420
分子式 : C18H19ClN4
纯度 : 99%+
分子量 : 326.823
MDL号 : MFCD06798338
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(321.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 FAUC 213 is an orally active, highly selective complete antagonist of the dopamine D4 receptor with a Ki of 2.2 nM for hD4.4, displaying minimal activity on D2 and D3 receptors (Ki of 3.4 μM and 5.3 μM for hD2 and hD3, respectively). FAUC 213 can cross the blood-brain barrier and exhibits characteristics of an atypical antipsychotic[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.30mL

3.06mL

1.53mL

30.60mL

6.12mL

3.06mL
参考文献

[1]Frank Boeckler, et al. FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology (Berl). 2004 Aug;175(1):7-17.