货号:A188600
同义名:
(S)-Omeprazole sodium;Esomeprazole sodium
Esomeprazole sodium, the sodium salt of esomeprazole which has the effect of reducing gastric acid secretion.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | ATPase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(-)-Blebbistatin | 99%+ | ||||||||||||||||||
PF 03716556 |
++++
H+/K+-ATPase, pIC50: ~6.5 |
99%+ | |||||||||||||||||
Esomeprazole sodium | ✔ | 98% | |||||||||||||||||
BTB06584 | ✔ | 99%+ | |||||||||||||||||
Ciclopirox | ✔ | 99%+ | |||||||||||||||||
CB-5083 |
++++
p97 AAA ATPase, IC50: 11 nM |
99%+ | |||||||||||||||||
Ciclopirox olamine | ✔ | 99% | |||||||||||||||||
Brefeldin A |
+++
ATPase (HCT 116), IC50: 0.2 μM |
99%+ | |||||||||||||||||
Oligomycin A | ✔ | 99% | |||||||||||||||||
Sodium orthovanadate |
+++
(Na,K)-ATPase, IC50: 40 nM |
99% | |||||||||||||||||
Golgicide A | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | Proton Pump ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zinc pyrithione | ✔ | 99%+ | |||||||||||||||||
PF 03716556 |
++++
H+/K+-ATPase, pIC50: ~6.5 |
99%+ | |||||||||||||||||
Lansoprazole | ✔ | 98% | |||||||||||||||||
Esomeprazole Magnesium | ✔ | 98%+ | |||||||||||||||||
Rabeprazole | ✔ | 99%+ | |||||||||||||||||
Ilaprazole | ✔ | TOPK | 97% | ||||||||||||||||
Bafilomycin A1 |
++++
H+-ATPase, IC50: 0.44 nM |
99%+ | |||||||||||||||||
Pantoprazole sodium | ✔ | 98% | |||||||||||||||||
(R)-Lansoprazole | ✔ | 98% | |||||||||||||||||
Tenatoprazole | ✔ | 99%+ | |||||||||||||||||
Omeprazole | ✔ | 98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Esomeprazole sodium ((S)-Omeprazole sodium) is a powerful and orally active inhibitor of the proton pump, decreasing acid production by targeting the H+, K+-ATPase in the gastric parietal cells. Furthermore, Esomeprazole sodium impedes exosome release by inhibiting V-H+-ATPases, acting as an exosome inhibitor[4]. Esomeprazole is noted for its research potential in addressing symptomatic gastroesophageal reflux disease[1].[2].[3]. |
体内研究 | Administering Esomeprazole (30-300 mg/kg; orally via gavage; daily; for 19 or 11 days; in C57BL/6J mice) significantly curbs the advancement of fibrosis in the lungs of these animals and diminishes circulating indicators of inflammation and fibrosis[2]. |
体外研究 | In vitro, Esomeprazole (25-100 µM; for 20 hours; MDA-MB-468 cells) administration curtails the growth of triple-negative breast cancer cells in a concentration-dependent manner, attributed to an increase in intracellular acidification[1]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03383003 | Helicobacter Pylori Infection | Not Applicable | Completed | - | Taiwan ... 展开 >> Wei-Chen Tai Kaohsiung, Taiwan, 833 收起 << |
NCT02711176 | Helicobacter Infection | Phase 4 | Completed | - | Iran, Islamic Republic of ... 展开 >> Ilam University of Medical Scienvc Ilam, Iran, Islamic Republic of, 6939177143 收起 << |
NCT03444402 | GERD | Phase 1 | Completed | - | Korea, Republic of ... 展开 >> Seoul University Hospital Seoul, Korea, Republic of 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.72mL 0.54mL 0.27mL |
13.61mL 2.72mL 1.36mL |
27.22mL 5.44mL 2.72mL |
CAS号 | 161796-78-7 |
分子式 | C17H18N3NaO3S |
分子量 | 367.398 |
别名 | (S)-Omeprazole sodium;Esomeprazole sodium;(-)-Omeprazole sodium |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(285.79 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(272.18 mM),配合低频超声助溶 无水乙醇: 50 mg/mL(136.09 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇 |
动物实验配方 |