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/ Esomeprazole sodium

埃索美拉唑钠 /Esomeprazole sodium 98%

货号：A188600 同义名： (S)-Omeprazole sodium;Esomeprazole sodium Ambeed 开学季，买赠积分，赢豪礼

Esomeprazole sodium, the sodium salt of esomeprazole which has the effect of reducing gastric acid secretion.

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Esomeprazole sodium 化学结构 CAS号：161796-78-7
Esomeprazole sodium 化学结构
CAS号：161796-78-7
Esomeprazole sodium 3D分子结构
CAS号：161796-78-7
Esomeprazole sodium 化学结构 CAS号：161796-78-7
Esomeprazole sodium 3D分子结构 CAS号：161796-78-7
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Esomeprazole sodium 纯度/质量文件 产品仅供科研

货号：A188600 标准纯度： 98%
批次查询： 批次纯度:

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产品名称 ATPase ↓ 其他靶点 纯度
(-)-Blebbistatin 99%+
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		99%+
Esomeprazole sodium ✔ 98%
BTB06584 ✔ 99%+
Ciclopirox ✔ 99%+
CB-5083 ++++

p97 AAA ATPase, IC50: 11 nM

 		99%+
Ciclopirox olamine ✔ 99%
Brefeldin A +++

ATPase (HCT 116), IC50: 0.2 μM

 		99%+
Oligomycin A ✔ 99%
Sodium orthovanadate +++

(Na,K)-ATPase, IC50: 40 nM

 		99%
Golgicide A ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Proton Pump ↓ 其他靶点 纯度
Zinc pyrithione ✔ 99%+
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		99%+
Lansoprazole ✔ 98%
Esomeprazole Magnesium ✔ 98%+
Rabeprazole ✔ 99%+
Ilaprazole ✔ TOPK 97%
Bafilomycin A1 ++++

H+-ATPase, IC50: 0.44 nM

 		99%+
Pantoprazole sodium ✔ 98%
(R)-Lansoprazole ✔ 98%
Tenatoprazole ✔ 99%+
Omeprazole ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Esomeprazole sodium 生物活性

靶点

  • ATPase
描述 Esomeprazole sodium ((S)-Omeprazole sodium) is a powerful and orally active inhibitor of the proton pump, decreasing acid production by targeting the H+, K+-ATPase in the gastric parietal cells. Furthermore, Esomeprazole sodium impedes exosome release by inhibiting V-H+-ATPases, acting as an exosome inhibitor[4]. Esomeprazole is noted for its research potential in addressing symptomatic gastroesophageal reflux disease[1].[2].[3].
体内研究

Administering Esomeprazole (30-300 mg/kg; orally via gavage; daily; for 19 or 11 days; in C57BL/6J mice) significantly curbs the advancement of fibrosis in the lungs of these animals and diminishes circulating indicators of inflammation and fibrosis[2].
体外研究

In vitro, Esomeprazole (25-100 µM; for 20 hours; MDA-MB-468 cells) administration curtails the growth of triple-negative breast cancer cells in a concentration-dependent manner, attributed to an increase in intracellular acidification[1].

Esomeprazole sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03383003 Helicobacter Pylori Infection Not Applicable Completed - Taiwan ... 展开 >> Wei-Chen Tai Kaohsiung, Taiwan, 833 收起 <<
NCT02711176 Helicobacter Infection Phase 4 Completed - Iran, Islamic Republic of ... 展开 >> Ilam University of Medical Scienvc Ilam, Iran, Islamic Republic of, 6939177143 收起 <<
NCT03444402 GERD Phase 1 Completed - Korea, Republic of ... 展开 >> Seoul University Hospital Seoul, Korea, Republic of 收起 <<

Esomeprazole sodium 参考文献

[1]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46.

[2]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.

[3]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

[4]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

Esomeprazole sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.61mL

2.72mL

1.36mL

27.22mL

5.44mL

2.72mL

Esomeprazole sodium 技术信息

CAS号161796-78-7
分子式C17H18N3NaO3S
分子量 367.398
别名 (S)-Omeprazole sodium;Esomeprazole sodium;(-)-Omeprazole sodium
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(285.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(272.18 mM)，配合低频超声助溶

无水乙醇: 50 mg/mL(136.09 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: Esomeprazole | 161796-78-7 | (S)-Omeprazole | (-)-Omeprazole | Proton Pump Inhibitor | Membrane Transporter/Ion Channel | Anti-infection | Proton Pump | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Esomeprazole sodium 纯度/质量文件 | Esomeprazole sodium 亚型比较 | Esomeprazole sodium 生物活性 | Esomeprazole sodium 临床数据 | Esomeprazole sodium 参考文献 | Esomeprazole sodium 实验方案 | Esomeprazole sodium 技术信息

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