Oligomycin A, a mitochondrial ATP synthase inhibitor, is isolated from Streptomyces species, exhibits anti-tumor and antibiotic activity.
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描述 | Oligomycin is a macrolide antibiotic, usually used as a potent inhibitor of mitochondrial F0F1-ATPase and oxidative phosphorylation, with Ki value of 1μM for inhibition of yeast intact mitochondrial ATPase activity and 0.1μM for Triton X-100-solubilized mitochondria[1]. Oligomycin at concentration of 1.5-3μM stimulated lysosome acidification due to shunting of membrane potential[2]. Treatment with 2.5μM oligomycin dramatically reduced ATP level in MII oocytes exposure to H2O2[3]. Oligomycin A exhibited antiproliferative effect on the JARID1B high subpopulation of WM3734 cells at concentration ranging in 0.1-10μg/ml post 24-72h due to the inhibition of mitochondrial respiration[4]. |
作用机制 | Oligomycin could bind to the c10 ring of the of the yeast mitochondrial ATP synthase thereby making contact with two neighboring molecules at a position. The carboxyl side chain of Glu59, which is essential for proton translocation, forms an H-bond with oligomycin.[5] |
Dose | Mice: 0.1 mg/kg[6] (i.p.), 2.25 mg/kg[7] (i.v.) |
Administration | i.p., i.v. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.26mL 0.25mL 0.13mL |
6.32mL 1.26mL 0.63mL |
12.64mL 2.53mL 1.26mL |
CAS号 | 579-13-5 |
分子式 | C45H74O11 |
分子量 | 791.062 |
别名 | MCH 32 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(132.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 无水乙醇: 100 mg/mL(126.41 mM),配合低频超声,并水浴加热至45℃助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇 |
动物实验配方 |