产品说明书
Esomeprazole sodium
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同义名 : | (S)-Omeprazole sodium;Esomeprazole sodium;(-)-Omeprazole sodium |
| CAS号 : | 161796-78-7 | |
| 货号 : | A188600 | |
| 分子式 : | C17H18N3NaO3S | |
| 纯度 : | 98% | |
| 分子量 : | 367.398 | |
| MDL号 : | MFCD07802816 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(285.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(272.18 mM)，配合低频超声助溶 无水乙醇: 50 mg/mL(136.09 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | Esomeprazole sodium ((S)-Omeprazole sodium) is a powerful and orally active inhibitor of the proton pump, decreasing acid production by targeting the H+, K+-ATPase in the gastric parietal cells. Furthermore, Esomeprazole sodium impedes exosome release by inhibiting V-H+-ATPases, acting as an exosome inhibitor[4]. Esomeprazole is noted for its research potential in addressing symptomatic gastroesophageal reflux disease[1].[2].[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03383003 | Helicobacter Pylori Infection | Not Applicable | Completed | - | Taiwan ... 展开 >> Wei-Chen Tai Kaohsiung, Taiwan, 833 收起 << |
| NCT02711176 | Helicobacter Infection | Phase 4 | Completed | - | Iran, Islamic Republic of ... 展开 >> Ilam University of Medical Scienvc Ilam, Iran, Islamic Republic of, 6939177143 收起 << |
| NCT03444402 | GERD | Phase 1 | Completed | - | Korea, Republic of ... 展开 >> Seoul University Hospital Seoul, Korea, Republic of 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.72mL 0.54mL 0.27mL |
13.61mL 2.72mL 1.36mL |
27.22mL 5.44mL 2.72mL |
| 参考文献 |
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