D-鞘氨醇 /D-Sphingosine
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货号：A536742
同义名：
鞘氨醇
/ Erythrosphingosine;trans-4-Sphingenine
D-Sphingosine inhibits protein kinase C.
D-Sphingosine 化学结构
D-Sphingosine 3D分子结构
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D-Sphingosine 纯度/质量文件 产品仅供科研
货号：A536742
标准纯度：
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产品说明书
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D-Sphingosine 质控信息
Daphnetin
+
EGFR,PKA
95%
Dequalinium Chloride
99%+
Quercetin
✔
Src,Sirtuin
97%
Myricetrin
✔
96%
Go 6983
+++
+++
+++
+++
++
99%+
Go6976
+++
++++
+++
FLT3
99%+
Bisindolylmaleimide I
+++
+++
PKCβ2, IC50: 16 nM
PKCβ1, IC50: 17 nM
+++
99%+
Lawsone methyl ether
✔
99%
Sotrastaurin
++++
++++
++++
++++
++++
++++
99%+
Enzastaurin
++
+++
+
+
98%
Midostaurin
++
++
PKCβ2, IC50: 31 nM
PKCβ1, IC50: 30 nM
++
+
+
+
99%
Ro 31-8220 mesylate
++++
+++
PKCβ2, IC50: 14 nM
PKCβ1, IC50: 24 nM
++
++
99%+
Staurosporine
++++
++++
+++
++
++++
99%+
Ruboxistaurin HCl
+
++++
PKCβ2, IC50: 5.9 nM
PKCβ1, IC50: 4.7 nM
+
+
++
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
D-Sphingosine 生物活性
描述
Protein kinase C, a family of related serine/threonine kinases implicated in multiple signal transduction pathways, exhibits antitumor property in mammalian cells. D-erythro-Sphingosine is a PKC inhibitor with an EC50 value of 8 ± 3 μM for p32. Treatment of Jurkat T cells with D-erythro-Sphingosine led to a ~4-fold increase in p32 phosphorylation, with the maximal effect observed at 10 μM[1] [2]
D-Sphingosine 参考文献
[1] Pushkareva MYu, Bielawska A, Menaldiv D, Liotta D, Hannun YA. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 (Pt 3)(Pt 3):699-703. doi: 10.1042/bj2940699
[2] Cheng P, Chen K, Yu W, Gao S, Hu S, Sun X, Huang H. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359(1-2):48-56. doi: 10.1016/j.jns.2015.10.025
D-Sphingosine 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.34mL
0.67mL
0.33mL
16.69mL
3.34mL
1.67mL
33.39mL
6.68mL
3.34mL
D-Sphingosine 技术信息
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