RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 enzyme with IC50 value of 0.58 nM, without activity against the SHP2 catalytic domain up to a concentration of 10 µM.

BR-1 is a cell-permeable PRL-3 inhibitor with IC50 value of 900nM. It dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration.

FRJ is a specific inhibitor of protein tyrosine phosphatase 1B (PTP1B).

BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09 - 1.7 μM, displaying irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. BVT 948 enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo.

Aloe-emodin-8-O-β-D-glucopyranoside是一种从芦荟中提取的蒽醌类化合物，具有抗炎、抗肿瘤和抗病毒活性，作为一种hPTP1B 抑制剂，其 IC50 值为 26.6 μM。。

Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.

PTP1B-IN-22是 ZINC02765569 的衍生物，作为有效的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，能够在骨骼肌 L6 肌管中抑制 PTP1B 并促进葡萄糖摄取。

SHIP2-IN-1是一种有效的 SHIP2 抑制剂，IC₅₀ 为 2 µM，可通过促进 GSK3β Ser9 位点的磷酸化，抑制其活化，适用于阿尔茨海默症等神经退行性疾病的研究。

TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].

NCGC00378430NCGC00378430 是一种有效的 SIX1/EYA2 相互作用抑制剂。它可以部分逆转 SIX1 过表达所介导的转录和代谢谱，并逆转 SIX1 诱导的 TGF-β 信号通路及上皮-间质转化 (EMT)。在小鼠模型中，NCGC00378430 也抑制了 SIX1 介导的乳腺癌转移。

PHPS1 is a potent and selective SHP2 inhibitor with Ki value of 0.73μM.

MP07-66是 FTY720 类似物，能够重新激活 PP2A，展现出抗肿瘤和免疫调节的潜力。

PTP Inhibitor I is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor, it binds to PTPs with Ki values of 43 and 42 μM and Kinact values of 0.40 and 0.57/min for SHP-1(△SH2) and PTP1B, respectively.

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

SHP099是一种高效、选择性和口服可用的SHP2抑制剂，IC50为70 nM。

GSK 2830371是一种高度选择性的Wip1磷酸酶抑制剂，IC50为6 nM。

Ceramide is a potent modulator of cell proliferation and differentiation.

DG013A是一种次膦酸三肽模拟抑制剂，对 ERAP1 和 ERAP2 的 IC₅₀ 分别为 33 nM 和 11 nM，适用于自身免疫性疾病和癌症的研究。

(E)-BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). (E)-BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively, but does not inhibit DUSP5.

BTdCPU is acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNAi), a key regulatory step of translation initiation.