酒石酸溴莫尼定 /Brimonidine tartrate
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货号：A139688
同义名：
AGN190342 tartrate;UK 14304 tartrate
Brimonidine tartrate is an α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, used to treat glaucoma through a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.
Brimonidine tartrate 化学结构
Brimonidine tartrate 3D分子结构
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Brimonidine tartrate 纯度/质量文件 产品仅供科研
货号：A139688
标准纯度：
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Brimonidine tartrate 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
98%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2A-adrenergic receptor, pKi: 8.9
α2B-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2C, pKi: 7.2
adrenoceptor α2A, pKi: 7.1
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1A-adrenergic receptor, Ki: 3.7 nM
α1D-adrenergic receptor, Ki: 20 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
97%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
98%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Brimonidine tartrate 生物活性
描述
Brimonidine tartrate is a α2 adrenergic agonist and hydrophilic drug used for treatment of glaucoma. BRT-loaded (Brimonidine Tartarate) proniosomal gels showed an improved ocular bioavailability and sustained drug release from the prepared vesicles[3] [4] [5]
Brimonidine tartrate 参考文献
[1] Gao H, Qiao X, et al. Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells. Arch Ophthalmol. 2002 Jun;120(6):797-803.
[2] Gao H, et al. Arch Ophthalmol, 2002, 120(6), 797-803.
[3] Emad Eldeeb A, Salah S, Ghorab M. Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study. Drug Deliv. 2019 Dec;26(1):509-521. doi: 10.1080/10717544.2019.1609622. PMID: 31090464; PMCID: PMC6534210.
[4] Jackson JM, Knuckles M, Minni JP, Johnson SM, Belasco KT. The role of brimonidine tartrate gel in the treatment of rosacea. Clin Cosmet Investig Dermatol. 2015 Oct 23;8:529-38. doi: 10.2147/CCID.S58920. PMID: 26566370; PMCID: PMC4627400.
[5] Lee KY, Nakayama M, Aihara M, Chen YN, Araie M. Brimonidine is neuroprotective against glutamate-induced neurotoxicity, oxidative stress, and hypoxia in purified rat retinal ganglion cells. Mol Vis. 2010 Feb 17;16:246-51. PMID: 20161817; PMCID: PMC2822551.
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Brimonidine tartrate 实验方案
计算器
摩尔计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.26mL
0.45mL
0.23mL
11.31mL
2.26mL
1.13mL
22.61mL
4.52mL
2.26mL
Brimonidine tartrate 技术信息
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