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6-姜酚 /6-Gingerol {[allProObj[0].p_purity_real_show]}

货号:A103354 同义名: 6-姜辣素 / (S)-(+)-[6]Gingerol;[6]-Gingerol

6-Gingerol is activator transient receptor potential vanilloid receptor TRPV1 and TRP ankyrin receptor TRPA1 with EC50 of 3.3 µM and 10.4 µM. It's a natural chemical found in the rhizomes of ginger (Z. officinale).

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
6-Gingerol 化学结构 CAS号:23513-14-6
6-Gingerol 化学结构
CAS号:23513-14-6
6-Gingerol 3D分子结构
CAS号:23513-14-6
6-Gingerol 化学结构 CAS号:23513-14-6
6-Gingerol 3D分子结构 CAS号:23513-14-6
规格 价格 会员价 库存 数量
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6-Gingerol 纯度/质量文件 产品仅供科研

货号:A103354 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 AMPK 其他靶点 纯度
WZ4003 ++++

NUAK2, IC50: 100 nM

NUAK1, IC50: 20 nM

98+%
Dorsomorphin ++

AMPK, Ki: 109 nM

99%
HTH-01-015 +++

NUAK1 , IC50: 100 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

6-Gingerol 生物活性

描述 6-Gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. The height of the biofilm formed with 10 μM and 0 μM 6-gingerol was ~12 and ~25 μm, respectively. The growth of Pseudomonas aeruginosa was slightly inhibited by 0.1-100 μ m 6-gingerol[3]. Moreover,6-gingerol exhibited protective effects on apoptosis induced by Aβ1–42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of GSK-3β and enhancing the activation of Akt[4].

6-Gingerol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03268655 Colorectal Adenoma Not Applicable Not yet recruiting February 2020 United States, Minnesota ... 展开 >> Epidemiology Clinical Research Center Minneapolis, Minnesota, United States, 55415 收起 <<
NCT03089593 Healthy Volunteers Not Applicable Completed - Brazil ... 展开 >> Hospital das Clínicas Belo Horizonte, Minas Gerais, Brazil, 30130-100 收起 <<
NCT03028454 Muscle Soreness Not Applicable Completed - United States, Virginia ... 展开 >> Human Performance Laboratory Norfolk, Virginia, United States, 23529 收起 <<

6-Gingerol 参考文献

[1]Chang KW, Kuo CY. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6(10):3334-41.

[2]Radhakrishnan EK, Bava SV, et al. [6] -Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9(8):e104401.

[3]Kim HS, Lee SH, Byun Y, Park HD. 6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition. Sci Rep. 2015 Mar 2;5:8656. doi: 10.1038/srep08656. PMID: 25728862; PMCID: PMC4345325.

[4]Zeng GF, Zong SH, Zhang ZY, Fu SW, Li KK, Fang Y, Lu L, Xiao DQ. The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells. Rejuvenation Res. 2015 Oct;18(5):413-21. doi: 10.1089/rej.2014.1657. Epub 2015 Aug 20. PMID: 25811848; PMCID: PMC4620533.

6-Gingerol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.98mL

3.40mL

1.70mL

33.97mL

6.79mL

3.40mL

6-Gingerol 技术信息

CAS号23513-14-6
分子式C17H26O4
分子量 294.386
别名 6-姜辣素 ;(S)-(+)-[6]Gingerol;[6]-Gingerol
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(169.85 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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