HTH-01-015
99%+
货号：A321152
HTH-01-015 is a selective NUAK1 inhibitor, but not NUAK2, with IC50 of 100 nM, suppressing NUAK1-mediated MYPT1 phosphorylation.
HTH-01-015 化学结构
HTH-01-015 3D分子结构
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HTH-01-015 纯度/质量文件 产品仅供科研
货号：A321152
标准纯度：
99%+
产品说明书
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HTH-01-015 质控信息
WZ4003
++++
NUAK2, IC50: 100 nM
NUAK1, IC50: 20 nM
98+%
Dorsomorphin
++
99%
HTH-01-015
+++
99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
HTH-01-015 生物活性
靶点
描述
HTH-01-015 is a selective NUAK1 inhibitor with IC50 value of 100nM. HTH-01-015 at 10μM inhibited the phosphorylation of the only well-characterized substrate, MYPT1 (myosin phosphate-targeting subunit 1) that is phosphorylated by NUAK1 at Ser-445. HTH-01-015 significantly inhibited MEFs proliferation and migration in a wound-healing assay. HTH-01-015 inhibited the proliferation and impaired the invasive potential of U2OS cells in a 3D cell invasion assay. The 195 site of NUAK1 is important for the inactivation effect of HTH-01-015 for a mutation (A195T) renders NUAK1 ∼50-fold resistant to HTH-01-015[2]
HTH-01-015 参考文献
[1] Banerjee S, Buhrlage SJ, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.
[2] Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25. doi: 10.1042/BJ20131152. PMID: 24171924; PMCID: PMC3969223.
HTH-01-015 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.13mL
0.43mL
0.21mL
10.67mL
2.13mL
1.07mL
21.34mL
4.27mL
2.13mL
HTH-01-015 技术信息
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