PD-089828是一种 ATP 竞争性抑制剂，针对FGFR-1、PDGFR-β 和 EGFR的IC₅₀值分别为 0.15 µM, 1.76 µM 和 5.47 µM，同时对c-Src 酪氨酸激酶具备非竞争性抑制作用 (IC₅₀=0.18 µM)。该化合物还抑制MAPK途径 (IC₅₀=7.1 µM)，在多种细胞模型中表现出持续的活性。

Alofanib is a selective and allosteric inhibitor of FGFR2 with potential antitumor activity.

ASP5878 是一种口服活性的 FGFR 1、2、3 和 4 的抑制剂，IC50 值分别为 0.47 nM、0.6 nM、0.74 nM 和 3.5 nM，具有潜在的抗肿瘤活性。

Zidesamtinib是一种 ROS1 融合和抗性突变抑制剂，能够有效阻断 ROS1 融合蛋白的作用。它在肺癌和其他癌症研究中具有应用前景。

SSR128129E is an allosteric modulator of FGFR by binding to the extracellular FGFR domain.

H3B-6527 是一种口服活性、高选择性且共价的 FGFR4 抑制剂，IC50 小于 1.2 nM。它对 FGFR1-3 的 IC50 值分别为 320、1290 和 1060 nM。H3B-6527 表现出强大的抗癌活性。

AZD-4547（Fexagratinib ; ADSK091) 是一种有效的FGFR家族抑制剂，对FGFR1、FGFR2、FGFR3和FGFR4的IC50值分别为0.2 nM、2.5 nM、1.8 nM和165 nM。

BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM.

PD 166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 52.4 nM.

BLU9931 is an inhibitor of FGFR4 with IC50 of 3 nM and is less potent for FGFR1/2/3 (IC50 > 150 nM).

FGF401, an inhibitor of human fibroblast growth factor receptor 4 (FGFR4, IC50 = 1.1 nM), has potential antineoplastic activity.

CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.

Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白多糖的一部分，广泛表达在细胞表面和细胞外基质中。

Derazantinib is a fibroblast growth factor receptor (FGFR) inhibitor that has antitumor activity.

FGFR-IN-1 is a potent and highly selective FGFR inhibitor, used for antitumor treatment.

Pemigatinib, also known as INCB054828, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. FGFR inhibitor INCB054828 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells.

Nintedanib esylate (BIBF 1120 esylate) (BIBF 1120 esylate) 是一种有效的三重血管激酶抑制剂，对VEGFR1/2/3、FGFR1/2/3和PDGFRα/β的IC50值分别为34 nM/13 nM/13 nM、69 nM/37 nM/108 nM和59 nM/65 nM。

Nintedanib（BIBF 1120）是一种强效的三重血管激酶抑制剂，对VEGFR1/2/3、FGFR1/2/3和PDGFRα/β的IC50值分别为34 nM、13 nM、13 nM、69 nM、37 nM、108 nM、59 nM和65 nM。

Masitinib is an inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms.