Ferulic Acid | Coniferic acid;4-hydroxy-3-Methoxycinnamic Acid;Ferulic Acid, Methyl ferulate, trans-Ferulic acid, Coniferic acid, NSC 2821, NSC2821, NSC-2821;NSC 674320;NSC 51986;NSC 2821;Fumalic Acid | 3-甲氧基-4-羟基苯基丙烯酸 | Plant Standard | FGFR

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阿魏酸 /Ferulic Acid {[allProObj[0].p_purity_real_show]}

货号：A137025 同义名： 3-甲氧基-4-羟基苯基丙烯酸 / Coniferic acid;4-hydroxy-3-Methoxycinnamic Acid

Ferulic Acid is a naturally occuring phenolic phytochemical found in plant cell walls with antioxidant effect.

Ferulic Acid 化学结构
CAS号：1135-24-6

Ferulic Acid 3D分子结构
CAS号：1135-24-6

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Ferulic Acid 纯度/质量文件产品仅供科研

货号：A137025 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

FGFR 亚型比较

产品名称	FGFR ↓ ↑	FGFR1 ↓ ↑	FGFR2 ↓ ↑	FGFR3 ↓ ↑	FGFR4 ↓ ↑	其他靶点	纯度
Tyrphostin AG1296	+ FGFR (Swiss 3T3), IC50: 12.3 μM					PDGFR	99%+
Pazopanib	+ FGFR, IC50: 140 nM						99%
Erdafitinib	✔					RET	99%+
Gambogenic acid	✔						98+%
Sulfatinib		+++ FGFR1, IC50: 15 nM					99+%
Nintedanib esylate		+ FGFR1, IC50: 69 nM	++ FGFR2, IC50: 37 nM	+ FGFR3, IC50: 108 nM			98%
Zoligratinib		+++ FGFR1, IC50: 9.3 nM	+++ FGFR2, IC50: 7.6 nM	++ FGFR3, IC50: 22 nM	+ FGFR4, IC50: 290 nM		99%+
MK-2461		+ FGFR1, IC50: 65 nM	++ FGFR2, IC50: 39 nM	++ FGFR3, IC50: 50 nM			98%+
SU 5402		++ FGFR1, IC50: 30 nM					98%
Brivanib		+ FGFR1, IC50: 148 nM					99%+
Lucitanib		++ FGFR1, IC50: 17.5 nM	+ FGFR2, IC50: 82.5 nM				99%+
Ponatinib		++++ FGFR1, IC50: 2.2 nM					98%
PD-166866		+ FGFR1, IC50: 52.4 nM					98%
Narazaciclib		++ FGFR1, IC50: 26 nM				RET	99%+
Lactate		+++ FGFR1, IC50: 8 nM		+++ FGFR3, IC50: 9 nM		c-Kit,FLT3	85%
Lenvatinib mesylate		++ FGFR1, IC50: 46 nM				c-RET	99%
LY2874455		++++ FGFR1, IC50: 2.8 nM	++++ FGFR2, IC50: 2.6 nM	+++ FGFR3, IC50: 6.4 nM	+++ FGFR4, IC50: 6 nM		99%+
FIIN-2		+++ FGFR1, IC50: 3.09 nM	+++ FGFR2, IC50: 4.3 nM	++ FGFR3, IC50: 27 nM	++ FGFR4, IC50: 45.3 nM		98%
FIIN-3		+++ FGFR1, IC50: 13.1 nM	++ FGFR2, IC50: 21 nM	++ FGFR3, IC50: 31.4 nM	++ FGFR4, IC50: 35.3 nM		98%
Infigratinib		++++ FGFR1, IC50: 0.9 nM	++++ FGFR2, IC50: 1.4 nM	++++ FGFR3, IC50: 1.0 nM FGFR3 (K650E), IC50: 4.9 nM	+ FGFR4, IC50: 60 nM		99%+
Danusertib		++ FGFR1, IC50: 47 nM				RET	99%+
R1530		++ FGFR1, IC50: 28 nM					98%
ENMD-2076		+ FGFR1, IC50: 92.7 nM	+ FGFR2, IC50: 70.8 nM			RET,FLT3	98%
Dovitinib		+++ FGFR1, IC50: 8 nM		+++ FGFR3, IC50: 9 nM		c-Kit,FLT3	99%+
Sorafenib		+ FGFR1, IC50: 580 nM					99%
SSR128129E		+ FGFR1, IC50: 1.9 μM					99%+
AZD-4547		++++ FGFR1, IC50: 0.2 nM	++++ FGFR2, IC50: 2.5 nM	++++ FGFR3, IC50: 1.8 nM			98%
Lenvatinib		++ FGFR1, IC50: 46 nM				RET	98%
PD173074		++ FGFR1, IC50: ~25 nM					99%+
S49076		++ FGFR1, IC50: 18 nM	+++ FGFR2, IC50: 17 nM	+++ FGFR3, IC50: 15 nM			98%
Futibatinib		++++ FGFR1, IC50: 1.8 nM	++++ FGFR2, IC50: 1.4 nM	++++ FGFR3, IC50: 1.6 nM	+++ FGFR4, IC50: 3.7 nM		99%+
Ferulic Acid		+ FGFR1, IC50: 3.78 μM	+ FGFR2, IC50: 12.5 μM				98%
Nintedanib		+ FGFR1, IC50: 69 nM	++ FGFR2, IC50: 37 nM	+ FGFR3, IC50: 108 nM	+ FGFR4, IC50: 610 nM		99+%
ASP5878		++++ FGFR1, IC50: 0.47 nM	++++ FGFR2, IC50: 0.6 nM	++++ FGFR3, IC50: 0.74 nM	+++ FGFR4, IC50: 3.5 nM		98%
PRN1371		++++ FGFR1, IC50: 0.6 nM	++++ FGFR2, IC50: 1.3 nM	+++ FGFR3, IC50: 4.1 nM	++ FGFR4, IC50: 19.3 nM		99%
Derazantinib		+++ FGFR1, IC50: 4.5 nM	++++ FGFR2, IC50: 1.8 nM	+++ FGFR3, IC50: 4.5 nM	++ FGFR4, IC50: 34 nM	RET	99%+
ODM-203		+++ FGFR1, IC50: 11 nM	+++ FGFR2, IC50: 16 nM	+++ FGFR3, IC50: 6 nM	++ FGFR4, IC50: 35 nM		99%+
Pemigatinib		++++ FGFR1, IC50: 0.4 nM	++++ FGFR2, IC50: 0.5 nM	++++ FGFR3, IC50: 1.2 nM	++ FGFR4, IC50: 30 nM		99%+
SKLB 610			✔			PDGFR	99%+
Alofanib			✔				99%+
Lirafugratinib			✔				98%
Masitinib mesylate				✔		FAK	99%+
BLU9931				+ FGFR3, IC50: 150 nM	+++ FGFR4, IC50: 3 nM		99%+
BO-264				✔			99%+
Fisogatinib					+++ FGFR4, IC50: 5 nM		99%+
H3B-6527					++++ FGFR4, IC50: <1.2 nM		99%+
Roblitinib					++++ FGFR4, IC50: 1.9 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ferulic Acid 生物活性

靶点

FGFR2

FGFR2, IC50:12.5 μM
FGFR1

FGFR1, IC50:3.78 μM

描述

Ferulic Acid, a kind of phenolic compound isolated from Tetragonia tetragonioides, has many biological activities. In vitro studies, ferulic acid has whitening effect on the B16F10 mouse melanoma cell line and anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line, while shows no cytotoxicity at concentrations up to 20 μM^[1]. Besides this, it was found that ferulic acid could effectively inhibit the epidermal growth factor receptor (EGFR) in human breast cancer cells, through down-regulating the Tyr 1068 autophosphorylation^[2]. In vivo studies, ferulic acid has the ability of ameliorating the diabetes-induced cognition lesions in rat via the regulation of protein tyrosine phosphatase 1B (PTP1B) and insulin signaling pathway^[3]. In addition, ferulic acid could contribute to the reversal of inflammatory response induced by chronic unpredictable mild stress (CUMS) in mice^[4].

Ferulic Acid 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03092076	Healthy	Phase 1	Completed	-	-
NCT01982734	Pharmacokinetics of New Curcum... 展开 >>in Formulations Safety of New Curcumin Formulations 收起 <<	Early Phase 1	Completed	-	Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT02944084	Safety After Oral Intake ... 展开 >> Pharmacokinetics After Oral Intake 收起 <<	Early Phase 1	Completed	-	Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<

Ferulic Acid 参考文献

[1]Park HJ, Cho JH, et al. Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells. J Nat Med. 2018;72(1):127-135.

[2]Sudhagar S, Sathya S, et al. Inhibition of epidermal growth factor receptor by ferulic acid and 4-vinylguaiacol in human breast cancer cells. Biotechnol Lett. 2018;40(2):257-262.

[3]Wang H, Sun X, et al. Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiol Behav. 2017.

[4]Liu YM, Shen JD, et al. Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress. Int Immunopharmacol. 2017.

Ferulic Acid 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.52mL

25.75mL

5.15mL

2.57mL

51.50mL

10.30mL

5.15mL

Ferulic Acid 技术信息

CAS号	1135-24-6
分子式	C₁₀H₁₀O₄
分子量	194.184

别名	3-甲氧基-4-羟基苯基丙烯酸 ;Coniferic acid;4-hydroxy-3-Methoxycinnamic Acid;Ferulic Acid, Methyl ferulate, trans-Ferulic acid, Coniferic acid, NSC 2821, NSC2821, NSC-2821;NSC 674320;NSC 51986;NSC 2821;Fumalic Acid
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(540.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

NCT03092076	Healthy	Phase 1	Completed	-	-
NCT01982734	Pharmacokinetics of New Curcum... 展开 >>in Formulations Safety of New Curcumin Formulations 收起 <<	Early Phase 1	Completed	-	Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT02944084	Safety After Oral Intake ... 展开 >> Pharmacokinetics After Oral Intake 收起 <<	Early Phase 1	Completed	-	Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT01293175	Overweight	Not Applicable	Completed	-	Italy ... 展开 >> Department of Food Science Portici, Italy, 80055 收起 <<
NCT02150356	Glucose and Lipid Metabolism ... 展开 >> Incretin Hormones Plasma Levels Inflammation, Oxidative Stress and Endothelial Function 收起 <<	Not Applicable	Completed	-	Italy ... 展开 >> Dept. Clinical Medicine and Surgery, Federico II University Naples, Italy, 80131 收起 <<
NCT02353234	Dietary Modification	Not Applicable	Completed	-	Italy ... 展开 >> University of Parma - Department of Food Science Parma, Italy, 43125 收起 <<
NCT03451760	Behavioral and Psychiatric Sym... 展开 >>ptoms of Dementia 收起 <<	Phase 2	Not yet recruiting	December 2019	-
NCT00777543	Healthy Males	Not Applicable	Completed	-	Netherlands ... 展开 >> University of Maastricht Maastricht, Netherlands, 6200 MD 收起 <<

阿魏酸 /Ferulic Acid {[allProObj[0].p_purity_real_show]}

Ferulic Acid 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Ferulic Acid 质控信息

Ferulic Acid 生物活性

Ferulic Acid 临床研究

Ferulic Acid 参考文献

Ferulic Acid 实验方案

Ferulic Acid 技术信息

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阿魏酸 /Ferulic Acid {[allProObj[0].p_purity_real_show]}

Ferulic Acid 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ferulic Acid 质控信息

Ferulic Acid 生物活性

Ferulic Acid 临床研究

Ferulic Acid 参考文献

Ferulic Acid 实验方案

Ferulic Acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Ferulic Acid 纯度/质量文件产品仅供科研