Sophoridine is naturally occuring alkaloid found in the plant Sophora flavescens, which could suppresses cell growth of human medulloblastoma through the inhibition of the FoxM1, NF‑κB and AP‑1 signaling pathway.
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Sophoridine is monomer alkaloids which extracts from Sophora alopecuroides L, is a potential antitumor natural product with high application value. Sophoridine exhibited remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μmol/L to 200 μmol/L[3]. Moreover, the cell proliferation of difference concentrations Sophoridine treated groups(134.62 ± 5.76%, 98.96 ± 4.88%, 80.26 ± 6.70% and 80.08 ± 5.65%) was significantly reduced compared with 0 μg/ml group. And Sophoridine had suppressed Hep G2 proliferation with dose-depend[4].
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