KH7 | KH 7 free | Soluble Adenylyl Cyclase Inhibitor | AmBeed-信号通路专用抑制剂

首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / cAMP / KH7

KH7 {[allProObj[0].p_purity_real_show]}

货号：A957502 同义名： KH 7 free

KH7是可溶性腺苷酸环化酶（sAC）的特异性抑制剂，在细胞中对重组sACt蛋白（人类和其他物种）的IC50为3-10 μM。KH7也是cAMP的抑制剂。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

KH7 化学结构
CAS号：330676-02-3

KH7 3D分子结构
CAS号：330676-02-3

规格	价格	会员价	库存	数量
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KH7 纯度/质量文件产品仅供科研

货号：A957502 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

cAMP 亚型比较

产品名称	AC ↓ ↑	EPAC1 ↓ ↑	EPAC2 ↓ ↑	纯度
Bithionol	+ sAC, IC50: 4.0 μM			{[allProObj[0].p_purity_real_show]}
SQ22536	✔			{[allProObj[0].p_purity_real_show]}
ESI-09		++ EPAC1, IC50: 3.2 μM	+++ EPAC2, IC50: 1.4 μM	{[allProObj[0].p_purity_real_show]}
HJC0350			+++ EPAC2, IC50: 0.3 μM	{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

KH7 生物活性

描述

Soluble adenylate cyclase (sAC) is a non-plasma membrane bound form of adenylate cyclase (AC) that produces the second messenger adenosine 3’,5’-cyclic AMP (cAMP) from ATP. It has been suggested to be involved in various cellular and physiological processes. KH 7, working as a classical uncoupler, is a sAC-specific inhibitor with an IC₅₀ of 2.7 μM. KH 7 at 25 μM inhibited ATP production by reducing respiration at lower concentrations and by perturbing membrane potential at higher concentrations in isolated mouse liver mitochondria^[2]. Application of the KH 7 showed almost complete inhibition of ATP-induced [Ca²⁺]_i elevation in pretreated EA.hy926 cells indicating it reduces intracellular Ca²⁺ response^[3]. In vivo, KH 7 (1.25 mM dissolved in 4 mL/kg DMSO) treatment caused an increased IOP (intraocular pressure) in avertin- and KXA(ketamine/xylazine/acepromazine)-anesthetized C57BL/6J mice compared with DMSO controls. In mice, KH 7 (5 μM) decreased outflow facility by 85.1% in nonanesthetized, enucleated eyes^[4].

KH7 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00035490	Arrhythmia	Phase 3	Completed	-	-
NCT03127059	Dysfunctional Breathing in Ast... 展开 >>hma 收起 <<	Not Applicable	Recruiting	November 2020	Denmark ... 展开 >> Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Silkeborg, Central Denmark Region, Denmark, 8600 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Bispebjerg, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Allergi og Lungeklinikken Helsingør Recruiting Helsingør, Danish Capital Region, Denmark, 3000 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Hvidovre, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Aalborg, Region North, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Naestved, Region Zealand, Denmark Contact: Karen H Andreasson, PT MSc +45 24 25 49 26 khad@regionsjaelland.dk Contact: Uffe Bødtger, MD PhD +45 56 51 45 92 ubt@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Roskilde, Region Zealand, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk 收起 <<
NCT03616912	Systemic Lupus Erythematosus	Phase 3	Recruiting	February 16, 2021	-

KH7 参考文献

[2]Jakobsen E, et al. The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. Biochem Pharmacol. 2018 Sep;155:92-101

[3]Mewes M, et al. Soluble adenylyl cyclase (sAC) regulates calcium signaling in the vascular endothelium. FASEB J. 2019 Dec;33(12):13762-13774

[4]Gandhi JK, et al. Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors. J Ocul Pharmacol Ther. 2017 Oct;33(8):574-581

KH7 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.92mL

2.38mL

1.19mL

23.85mL

4.77mL

2.38mL

KH7 技术信息

CAS号	330676-02-3
分子式	C₁₇H₁₅BrN₄O₂S
分子量	419.296

别名	KH 7 free
运输	蓝冰

存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 250 mg/mL(596.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00035490	Arrhythmia	Phase 3	Completed	-	-
NCT03127059	Dysfunctional Breathing in Ast... 展开 >>hma 收起 <<	Not Applicable	Recruiting	November 2020	Denmark ... 展开 >> Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Silkeborg, Central Denmark Region, Denmark, 8600 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Bispebjerg, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Allergi og Lungeklinikken Helsingør Recruiting Helsingør, Danish Capital Region, Denmark, 3000 Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Hvidovre, Danish Capital Region, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Aalborg, Region North, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Naestved, Region Zealand, Denmark Contact: Karen H Andreasson, PT MSc +45 24 25 49 26 khad@regionsjaelland.dk Contact: Uffe Bødtger, MD PhD +45 56 51 45 92 ubt@regionsjaelland.dk Dep. of Physiotherapy and Dep. of Pulmonology Recruiting Roskilde, Region Zealand, Denmark Contact: Karen H Andreasson khad@regionsjaelland.dk 收起 <<
NCT03616912	Systemic Lupus Erythematosus	Phase 3	Recruiting	February 16, 2021	-
NCT03518086	Ulcerative Colitis	Phase 3	Recruiting	December 29, 2021	-
NCT03524092	Ulcerative Colitis	Phase 3	Recruiting	March 22, 2022	-
NCT02100696	Ulcerative Colitis	Phase 3	Recruiting	December 26, 2020	-
NCT02136069	Ulcerative Colitis	Phase 3	Recruiting	March 30, 2023	-
NCT03383146	Gastroparesis ... 展开 >> Diabetes Mellitus 收起 <<	Phase 3	Recruiting	September 28, 2020	-
NCT01671007	-		Active, not recruiting	January 14, 2020	-
NCT02129699	Lung Cancer Non-small Cell Sta... 展开 >>ge IV 收起 <<	Phase 3	Active, not recruiting	September 2020	-
NCT02674308	-		Recruiting	June 30, 2022	-
NCT03094715	Stroke, Acute ... 展开 >> Cerebral Stroke Cerebrovascular Stroke Apoplexy; Brain 收起 <<	Not Applicable	Not yet recruiting	September 30, 2022	-
NCT02850172	Esophageal Cancer	Not Applicable	Recruiting	April 2019	Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 10048 Contact: Yu-Juan Xu +886-2-23123456 ext 88438 yujuanxu@kimo.com Contact: Cheryl Chia-Hui Chen +886-2-33222390 cherylchen@ntu.edu.tw 收起 <<
NCT02495922	Multiple Myeloma	Phase 3	Active, not recruiting	March 2021	-
NCT02690831	Manual Therapies ... 展开 >> Respiratory Muscle Training Exercise Therapy Inspiratory Capacity Asthma 收起 <<	Not Applicable	Completed	-	Spain ... 展开 >> Centro Superior de Estudios Universitarios La Salle Madrid, Spain, 28023 收起 <<
NCT00615940	Metastatic Breast Cancer	Phase 2	Completed	-	United States, New York ... 展开 >> Montefiore Medical Center Weiler Division Department New York, New York, United States, 10461 United States, Ohio Universitys Hospital Case Medical Center Cleveland, Ohio, United States, 44106 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 Belgium AZ Klina, Oncology Department Brasschaat, Belgium, 2930 Institut Jules Bordet Oncologie Médicale Bruxelles, Belgium, 1000 CHU de Liège, Domaine Universitaire de Sart-Tilman, Oncology Department Liège, Belgium, 4000 Brazil Irmandade de Misericórdia da Santa Casa de Porto Alegre Porto Alegre, Brazil, 9005 Instituto Nacional do Câncer - INCA Rio de Janeiro, Brazil, 20560 Instituto Brasileiro de Controle do Câncer - IBCC São Paulo, Brazil, 03102 Germany Gemeinschaftspraxis Dr. Brudler, Dr. Heinrich, Dr. Bangerter Augsburg, Germany, 86150 Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Uniklinik Köln Cologne, Germany Universitätsklinikum Essen, Innere Klinik und Poliklinik (Tumorforschung) Essen, Germany, 45147 Uniklinik Frankfurt, Zentrum der Frauenheilkunde und Geburtshilfe Frankfurt/Main, Germany, 60590 Universitätsklinikum der Martin-Luther-Universität Halle-Wittenberg, Poliklinik Gynäkologie Halle/Saale, Germany, 06120 Department of Obstetrics and Gynecology, Technical University Munich, Germany, 81675 Bethesda KH Mönchengladbach, Germany, 41061 Israel Davidof Center, Rabin Medical Center, Department of Oncology Petah Tikva, Israel, 49100 Kaplan Medical Center, Department of Oncolocy Rehovot, Israel, 76100 Sheba Medical Center, Department of Oncology Tel Hashomer, Israel, 52621 Assaf Harofeh medical center, Department of Oncology Zerifin, Israel, 70300 收起 <<
NCT02596893	Crohn Disease	Phase 3	Terminated(Study terminated by... 展开 >> Sponsor following a recommendation from external DMC based on lack of emerging benefit; there were no new emergent safety findings) 收起 <<	-	-
NCT01667601	Schizophrenia	Phase 2 Phase 3	Completed	-	China, Jilin ... 展开 >> Jilin Medical College Jilin, Jilin, China, 0432 Hong Kong KH/LKS Specialty OPD Shatin/Mongkok, NT/Kln, Hong Kong TM Psy Centre Tuen Mun, NT, Hong Kong Taiwan Taipei Medical University Taipei, Xinyi, Taiwan 收起 <<
NCT02283437	Schizophrenia Spectrum Disorde... 展开 >>rs Family Caregivers 收起 <<	Not Applicable	Active, not recruiting	December 31, 2018	Hong Kong ... 展开 >> KH; LKS Specialty OPD Shatin And Mongkok, NT/Kln, Hong Kong Li Ka Shing Specialty OPD Sha Tin, NT, Hong Kong 收起 <<
NCT01891227	Breast Cancer	Phase 2	Completed	-	Austria ... 展开 >> Hämatologie und Onkologie/Interne E, LKH Feldkirch Feldkirch, Austria, A-6807 Universitätsklinik f. Frauenheilkunde und Geburtshilfe, Klin. Abt. f. Gynäkologie Graz, Austria, 8036 Universitätsklinik f. Innere Medizin, Klin.Abt. f. Onkologie Graz, Austria, 8036 Univ.-Klinik f. Frauenheilkunde; Klinische Abt. f. Gynäkologie u. Geburtshilfe Innsbruck, Austria, A-6020 KH Barmh. Schwestern Linz, Innere Medizin I Hämatologie/Onkologie Linz, Austria, A-4010 Kepler Universitätsklinikum, Med Campus III, Klinik f. Interne 3 - Schwerpunkt Hämatologie u. Onkologie Linz, Austria, A-4021 Universitätsklinik für Innere Medizin III Salzburg, Austria, A-5020 Landeskrankenhaus Steyr, Interne Medizin II Steyr, Austria, A-4400 收起 <<
NCT01523639	Colorectal Cancer ... 展开 >> Steatohepatitis 收起 <<	Phase 2	Terminated(Prematurely due to ... 展开 >>slow recruitment (07/08/2013). Newly defined study end=LPLV=05/11/2013. ABCSG guaranteed completed treatment period for ethical reasons.) 收起 <<	May 2014	Austria ... 展开 >> Medical University Graz, Oncology Graz, Styria, Austria, 8036 Medical University Innsbruck, Internal Medicine Innsbruck, Tyrol, Austria, 6020 Hospital St. Vinzenz Zams, Tyrol, Austria, 6511 Hospital BHS Ried Ried, Upper Austria, Austria, 4910 KH BHB Vienna Vienna, Austria, 1021 Med. Univ. Vienna, General Hospital Vienna Vienna, Austria, 1090 KH St. Josef KH Vienna, Austria, 1130 收起 <<
NCT00688259	-		Completed	-	-
NCT00688259	Schizophrenia ... 展开 >> Schizoaffective Disorder 收起 <<	Not Applicable	Completed	-	United States, California ... 展开 >> VA Greater Los Angeles Healthcare System, West Los Angeles, CA West Los Angeles, California, United States, 90073 收起 <<
NCT02514161	Manual Therapies ... 展开 >> Respiratory Muscle Training Exercise Therapy Inspiratory Capacity 收起 <<	Not Applicable	Completed	-	Spain ... 展开 >> Centro Superior de Estudios Universitarios La Salle Madrid, Spain, 28023 收起 <<
NCT00975533	Type 2 Diabetes Mellitus	Phase 3	Unknown	October 2011	China, Hong Kong ... 展开 >> Prince of Wales Hospital Not yet recruiting Shatin, Hong Kong, China Principal Investigator: Simon KH Wong, MBChB Sub-Investigator: Alice PS Kong, MBChB Sub-Investigator: Ronald CW Ma, MBChB Sub-Investigator: Juliana CN Chan, MBBS Sub-Investigator: Enders KW Ng, MBChB Sub-Investigator: Vannessa WS Ng, MBChB Sub-Investigator: Francis CC Chow, MBBS Sub-Investigator: Wing Yee So, MBChB Sub-Investigator: Winnie CW Chu, MBChB 收起 <<
NCT02118584	Ulcerative Colitis	Phase 3	Recruiting	April 8, 2025	-
NCT00365937	Melanoma	Phase 1 Phase 2	Terminated(New regulatories of... 展开 >> the peptides by the pharmaceutical company (the seller)) 收起 <<	August 2009	Belgium ... 展开 >> Cliniques Universitaires Saint-Luc Brussels, Belgium, 1200 收起 <<
NCT01014026	Uterine Cervical Neoplasms ... 展开 >> Uterine Cervical Dysplasia 收起 <<	Phase 3	Completed	-	France ... 展开 >> IRSA 37 La Riche, France, 37521 IRSA 72 Le Mans, France, 72000 Service d'Orthogénie, CHRU Tours Tours, France, 37000 Service de Gynécologie, CHRU Tours Tours, France, 37000 Association Paul Metadier Tours, France 收起 <<
NCT03108352	Branch Retinal Vein Occlusion ... 展开 >> Macular Edema 收起 <<	Phase 3	Recruiting	December 2020	China ... 展开 >> Beijing Friendship Hospital, Capital Medical University Recruiting Beijing, China Contact: Yanling WANG Peking University People's Hospital Recruiting Beijing, China Contact: Xiaoxin LI Beijing Tongren Hospital, Capital Medical University Recruiting Peking, China Contact: wenbin WEI Zhongshan Hospital Recruiting Shanghai, China Contact: Fei YUAN Tianjin Medical University Eye Hospital Recruiting Tianjing, China Contact: Xiaorong LI The Eys Hosptial of Wenzhou Medical University Recruiting Wenzhou, China Contact: Xiaoling LIU The Frist Affiliated Hospital of Xi'an Jiaotong University Recruiting Xi'an, China Contact: Li QIN 收起 <<
NCT01588301	Cervical Cancer ... 展开 >> Human Papillomavirus Infection 收起 <<	Early Phase 1	Completed	-	-
NCT00741637	Cholera Vibri... 展开 >>o Infections Diarrhea 收起 <<	Phase 2	Completed	-	Thailand ... 展开 >> Department of Preventive and Social Medicine Siriraj Hospital Bangkok, Thailand, 10700 收起 <<
NCT02255084	Cancer Cervix	Not Applicable	Completed	-	France ... 展开 >> UH Tours Tours, Indre et Loire, France, 37000 收起 <<

KH7 {[allProObj[0].p_purity_real_show]}

KH7 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

KH7 质控信息

KH7 生物活性

KH7 临床研究

KH7 参考文献

KH7 实验方案

KH7 技术信息

最近浏览的产品

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KH7 {[allProObj[0].p_purity_real_show]}

KH7 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

KH7 质控信息

KH7 生物活性

KH7 临床研究

KH7 参考文献

KH7 实验方案

KH7 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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KH7 纯度/质量文件产品仅供科研