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Tanshinone IIA

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Chemical Structure| 568-72-9 同义名 : Dan Shen ketone;NSC 686518;TSA;NSC 686519;Tanshinone B
CAS号 : 568-72-9
货号 : A104838
分子式 : C19H18O3
纯度 : 97%
分子量 : 294.344
MDL号 : MFCD00238692
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(3.4 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5% DMSO+30% PEG 300+2% Tween 80+water 0.2 mg/mL

生物活性
靶点

  • Lipase
描述 Sodium tanshinone IIA sulfonate (STS) is one of the derivatives of tanshinone IIA (Tan IIA) which is a main lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen)[3].Tan-IIA reduces the production of inflammatory mediators and restores abnormal signaling pathways via regulating the function and activation of immune cells. It can also regulate signal transduction pathways, ie, TLR/NF-κB pathway and MAPKs/NF-κB pathway, thereby tan-IIA has an anti-inflammatory, anticoagulant, antithrombotic and neuroprotective role[4]. In vivo , echocardiography results showed that Tanshinone IIA could significantly improve heart function. Western Blot result showed that Tanshinone IIA treatment enhanced autophagy and regulated expressions of key autophagy-related molecules, including protein 1 light chain 3 (LC3), p62 and Beclin1. Tanshinone IIA also inhibited apoptosis and regulated expressions of key apoptotic protein, including B cell lymphoma-2 (Bcl-2) and Bcl-2 Associated X Protein (Bax) and cleaved caspase-3 and -7. Further experiments demonstrated that the effects of Tanshinone IIA were mediated through upregulation of AMPK and downregulation of mTOR simultaneously. The mTOR agonist MHY1485 could abrogate the therapeutic effect of Tanshinone IIA in vitro [5]. Tanshinone IIA has anti-adipogenic effects on 3T3-L1 cells and zebrafish, and its anti-adipogenic effect on 3T3-L1 cells is largely attributable to the reduced expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3/5[6].Tan IIA treatment of high-fat diet fed ApoE-/- mice significantly attenuated NLRP3 inflammasome activation In vivo . Consistently, Tan IIA also potently inhibited oxLDL-induced NLRP3 inflammasome activation in mouse macrophages[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.99mL

3.40mL

1.70mL

33.97mL

6.79mL

3.40mL
参考文献

[1]Fu J, Huang H, et al. Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. Eur J Pharmacol. 2007 Jul 30;568(1-3):213-21.

[2]Wang X, Wei Y, et al. Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer. 2005 Sep 20;116(5):799-807.

[3]Zhong-Yan Zhou,et al. Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics, Biomed Pharmacother. 2019 Oct;118:109362.

[4]Rui Guo,et al. Drug Des Devel Ther. 2020 Nov 5;14:4735-4748.

[5]Xuefeng Zhang,et al. Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs/mTOR-dependent autophagy pathway. Biomed Pharmacother. 2019 Apr;112:108599.

[6]Yu-Kyoung Park,et al. Anti-Adipogenic Effects on 3T3-L1 Cells and Zebrafish by Tanshinone IIA. Int J Mol Sci. 2017 Sep 27;18(10):2065.

[7]Jiexia Wen,et al. Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation. Aging (Albany NY). 2020 Nov 16;13(1):910-932.