原苏木素B /Protosappanin B {[allProObj[0].p_purity_real_show]}
货号：A189663同义名：
FT-0689654;Q-100961
Protosappanin B, a natural product isolated and purified from the heart wood of Caesalpinia sappan L., significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43, and induces the degradation ofp53 protein, via activation of a MDM2-dependent ubiquitination process.
Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity. Protosappanin B (2 mg/mL) reduced the viability of human bladder cancer T24 cells and mouse bladder cancer BTT cells in a time-dependent manner and significantly inhibited the growth of the human colon cancer cell lines HCT-116 and SW-480. IC50 values of 21.32, 26.73, and 76.53 µg/mL were obtained for SW-480, HCT-116, and BTT cells, respectively, after 48 hours of treatment with protosappanin B. In addition, pretreatment of H22 cells with protosappanin B (final concentration = 6.25 mg/mL) resulted in complete inhibition of tumor formation in KM mice. Furthermore, protosappanin B (200 and 300 mg/kg) significantly increased the survival of BTT tumor-bearing T739 mice, at a rate comparable to that of 1 mg/kg mitomycin[3]. PSB (Protosappanin B) effectively inhibited the viability and migration of SW620 cells and induced apoptosis, but had poor effect on HCT116 cells[4]. PTB (Protosappanin B) significantly increased cell viability, inhibited cell apoptosis and up-regulated the expression of growth-associated protein 43 (a marker of neural outgrowth)[5].
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