产品说明书
Protosappanin B
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同义名 : | FT-0689654;Q-100961;(-)-Protosappanin B |
| CAS号 : | 102036-29-3 | |
| 货号 : | A189663 | |
| 分子式 : | C16H16O6 | |
| 纯度 : | 99%+ | |
| 分子量 : | 304.295 | |
| MDL号 : | MFCD29048516 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(164.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity. Protosappanin B (2 mg/mL) reduced the viability of human bladder cancer T24 cells and mouse bladder cancer BTT cells in a time-dependent manner and significantly inhibited the growth of the human colon cancer cell lines HCT-116 and SW-480. IC50 values of 21.32, 26.73, and 76.53 µg/mL were obtained for SW-480, HCT-116, and BTT cells, respectively, after 48 hours of treatment with protosappanin B. In addition, pretreatment of H22 cells with protosappanin B (final concentration = 6.25 mg/mL) resulted in complete inhibition of tumor formation in KM mice. Furthermore, protosappanin B (200 and 300 mg/kg) significantly increased the survival of BTT tumor-bearing T739 mice, at a rate comparable to that of 1 mg/kg mitomycin[3]. PSB (Protosappanin B) effectively inhibited the viability and migration of SW620 cells and induced apoptosis, but had poor effect on HCT116 cells[4]. PTB (Protosappanin B) significantly increased cell viability, inhibited cell apoptosis and up-regulated the expression of growth-associated protein 43 (a marker of neural outgrowth)[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.29mL 0.66mL 0.33mL |
16.43mL 3.29mL 1.64mL |
32.86mL 6.57mL 3.29mL |
| 参考文献 |
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