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Phytohemagglutinin
植物血凝素 /Phytohemagglutinin
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货号：A1145366
同义名：
植物血球凝集素
/ PHA-M;Phaseolus vulgaris agglutinin
Phytohemagglutinin (PHA-M), a lectin extract from the red kidney bean and a standard T cell mitogen, as an inhibitor of both T- and B-cell tumors. Phytohemagglutinin can inhibit incorporation of 3H-thymidine and mediate apoptosis of B- and T-cell tumor lines. Anti-tumor activity .
Phytohemagglutinin 化学结构
Phytohemagglutinin 3D分子结构
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数量
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Phytohemagglutinin 质控信息
BTSA1
✔
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HA14-1
+
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Venetoclax
++++
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Navitoclax
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Obatoclax Mesylate
+++
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ABT-737
+++
+
+++
+++
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Gambogic Acid
+
Bcl-2, IC50: 1.21 μM
Bfl-1, IC50: 1.06 μM
++
++++
+
+
++
Caspase
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BH3I-1
+
BH3-Bcl-xL interaction, Ki: 2.4 μM
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A-1331852
++++
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A-1210477
++++
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Maritoclax
✔
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TW-37
+++
+
+++
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UMI-77
++
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(R)-(-)-Gossypol acetic acid
++
++
+++
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Sabutoclax
++
Bcl-2, IC50: 0.32 μM
Bfl-1, IC50: 0.62 μM
++
++
+++
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Emricasan
✔
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Z-VAD(OMe)-FMK
✔
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Z-VAD-FMK
✔
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Q-VD-OPh
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VX-765
++++
++++
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Ac-DEVD-CHO
+++
+++
+++
+
++++
++
++
+++
++++
++
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Z-DEVD-FMK
✔
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Z-IETD-FMK
✔
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展开
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Phytohemagglutinin 生物活性
描述
Phytohemagglutinin M (PHAM) has been purified from the commercial mixture of proteins produced by Phaseolus vulgaris, using a Sepharose-thyroglobulin column[4] [5] [6] [7]
Phytohemagglutinin 参考文献
[1] D'Costa SS, et al. Phytohemagglutinin inhibits lymphoid tumor growth in vitro and in vivo. Leuk Lymphoma. 2003;44(10):1785-1791.
[2] Merlo JL, et al. Food Restriction Affects Inflammatory Response and Nutritional State in Tuco-tucos (Ctenomys talarum). J Exp Zool A Ecol Genet Physiol. 2016 Dec;325(10):675-687.
[3] Kochubei TO, et al. Isolectins of phytohemagglutinin are able to induce apoptosis in HEp-2 carcinoma cells in vitro. Exp Oncol. 2015 Jun;37(2):116-9.
[4] Dupuis G. The binding of phytohemagglutinin M to rat spleen lymphocytes. Quantitative studies. Can J Biochem. 1976;54(8):717‐728
[5] Téllez-Bañuelos MC, González-Ochoa S, Ortiz-Lazareno PC, Rosas-Gonzalez VC, Gómez-Villela J, Haramati J. Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells. J Immunotoxicol. 2019;16(1):173‐181
[6] Paßlack N, Kohn B, Doherr MG, Zentek J. Impact of Dietary Protein Concentration and Quality on Immune Function of Cats. PLoS One. 2017;12(1):e0169822. Published 2017 Jan 10
[7] Klein S, Parvizi N. Visualization of immunoreactive growth hormone in cultured peripheral bovine lymphocytes. Growth Horm IGF Res. 2012;22(2):59‐63
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Phytohemagglutinin 技术信息
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