TW-37 | Bcl-2 Family Inhibitor | AmBeed-信号通路专用抑制剂

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TW-37 {[allProObj[0].p_purity_real_show]}

货号：A252493

TW-37 is a nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

TW-37 化学结构
CAS号：877877-35-5

TW-37 3D分子结构
CAS号：877877-35-5

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TW-37 纯度/质量文件产品仅供科研

货号：A252493 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

Bcl-2 亚型比较

产品名称	Bax ↓ ↑	Bcl-2 ↓ ↑	Bcl-B ↓ ↑	Bcl-w ↓ ↑	Bcl-xL ↓ ↑	Bfl-1 ↓ ↑	Mcl-1 ↓ ↑	其他靶点	纯度
BTSA1	✔								99%+
HA14-1		+ Bcl-2, IC50: 9 μM							98%
Venetoclax		++++ Bcl-2, Ki: <0.01 nM							99%
Navitoclax									99%+
Obatoclax Mesylate		+++ Bcl-2, Ki: 0.22 μM							98%
ABT-737		+++ Bcl-2, EC50: 30.3 nM	+ Bcl-B, EC50: 1.82 μM	+++ Bcl-w, EC50: 197.8 nM	+++ Bcl-xL, EC50: 78.7 nM				99%+
Gambogic Acid		+ Bfl-1, IC50: 1.06 μM Bcl-2, IC50: 1.21 μM	++ Bcl-B, IC50: 0.66 μM	++++ Bcl-w, IC50: 0.02 μM	+ Bcl-xL, IC50: 1.47 μM	+ Bfl-1, IC50: 1.06 μM	++ Mcl-1, IC50: 0.79 μM	Caspase	99% HPLC
BH3I-1					+ BH3-Bcl-xL interaction, Ki: 2.4 μM				98%
A-1331852					++++ Bcl-xL, Ki: <0.01 nM				99%+
A-1210477							++++ MCL-1, IC50: 26.2 nM		99%+
Maritoclax							✔		97%
TW-37		+++ Bcl-2, Ki: 0.29 μM			+ Bcl-xL, Ki: 1.11 μM		+++ Mcl-1, Ki: 0.26 μM		98%
UMI-77							++ Mcl-1, Ki: 490 nM		97%
(R)-(-)-Gossypol acetic acid		++ Bcl-2, Ki: 0.32 μM			++ Bcl-xL, Ki: 0.48 μM		+++ Mcl-1, Ki: 0.18 μM		98%
Sabutoclax		++ Bfl-1, IC50: 0.62 μM Bcl-2, IC50: 0.32 μM			++ Bcl-xL, IC50: 0.31 μM	++ Bfl-1, IC50: 0.62 μM	+++ Mcl-1, IC50: 0.20 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

TW-37 生物活性

靶点	Bcl-xL Bcl-xL, Ki:1.11 μM Mcl-1 Mcl-1, Ki:0.26 μM Bcl-2 Bcl-2, Ki:0.29 μM
描述	TW-37 is a nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

TW-37 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
human A204 cell		Growth inhibition assay		Inhibition of human A204 cell growth in a cell viability assay, IC50=97.84 nM	SANGER
human A2780 cell		Growth inhibition assay		Inhibition of human A2780 cell growth in a cell viability assay, IC50=0.21846 μM	SANGER
human A375 cell		Growth inhibition assay		Inhibition of human A375 cell growth in a cell viability assay, IC50=88.83 nM	SANGER
human A427 cell		Growth inhibition assay		Inhibition of human A427 cell growth in a cell viability assay, IC50=44.69 nM	SANGER

TW-37 参考文献

[1]Zeitlin BD, Spalding AC, et al. Metronomic small molecule inhibitor of Bcl-2 (TW-37) is antiangiogenic and potentiates the antitumor effect of ionizing radiation. Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):879-87.

[2]Wang et al (2009) TW-37, a small molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res. 69 2757.

TW-37 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.74mL

0.35mL

0.17mL

8.72mL

1.74mL

0.87mL

17.43mL

3.49mL

1.74mL

TW-37 技术信息

CAS号	877877-35-5
分子式	C₃₃H₃₅NO₆S
分子量	573.699

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 40 mg/mL(69.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

human A204 cell	Growth inhibition assay	Inhibition of human A204 cell growth in a cell viability assay, IC50=97.84 nM	SANGER
human A2780 cell	Growth inhibition assay	Inhibition of human A2780 cell growth in a cell viability assay, IC50=0.21846 μM	SANGER
human A375 cell	Growth inhibition assay	Inhibition of human A375 cell growth in a cell viability assay, IC50=88.83 nM	SANGER
human A427 cell	Growth inhibition assay	Inhibition of human A427 cell growth in a cell viability assay, IC50=44.69 nM	SANGER
human A549 cell	Growth inhibition assay	Inhibition of human A549 cell growth in a cell viability assay, IC50=14.09 nM	SANGER
human A673 cell	Growth inhibition assay	Inhibition of human A673 cell growth in a cell viability assay, IC50=53.85 nM	SANGER
human AGS cell	Growth inhibition assay	Inhibition of human AGS cell growth in a cell viability assay, IC50=37.53 nM	SANGER
human BHT-101 cell	Growth inhibition assay	Inhibition of human BHT-101 cell growth in a cell viability assay, IC50=21.83 nM	SANGER
human Ca9-22 cell	Growth inhibition assay	Inhibition of human Ca9-22 cell growth in a cell viability assay, IC50=3.82 nM	SANGER
human CHL-1 cell	Growth inhibition assay	Inhibition of human CHL-1 cell growth in a cell viability assay, IC50=11.9 nM	SANGER
human CP50-MEL-B cell	Growth inhibition assay	Inhibition of human CP50-MEL-B cell growth in a cell viability assay, IC50=69.59 nM	SANGER
human Daoy cell	Growth inhibition assay	Inhibition of human Daoy cell growth in a cell viability assay, IC50=0.14073 μM	SANGER
human DU-145 cell	Growth inhibition assay	Inhibition of human DU-145 cell growth in a cell viability assay, IC50=52.13 nM	SANGER
human GB-1 cell	Growth inhibition assay	Inhibition of human GB-1 cell growth in a cell viability assay, IC50=98.69 nM	SANGER
human GCIY cell	Growth inhibition assay	Inhibition of human GCIY cell growth in a cell viability assay, IC50=20.83 nM	SANGER
human HCT-116 cell	Growth inhibition assay	Inhibition of human HCT-116 cell growth in a cell viability assay, IC50=52.66 nM	SANGER
human HEC-1 cell	Growth inhibition assay	Inhibition of human HEC-1 cell growth in a cell viability assay, IC50=81.37 nM	SANGER
human HOS cell	Growth inhibition assay	Inhibition of human HOS cell growth in a cell viability assay, IC50=84.71 nM	SANGER
human Hs-578-T cell	Growth inhibition assay	Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50=23.59 nM	SANGER
human HT-144 cell	Growth inhibition assay	Inhibition of human HT-144 cell growth in a cell viability assay, IC50=0.15201 μM	SANGER
human HuH-7 cell	Growth inhibition assay	Inhibition of human HuH-7 cell growth in a cell viability assay, IC50=32.82 nM	SANGER
human HUTU-80 cell	Growth inhibition assay	Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50=87.01 nM	SANGER
human JAR cell	Growth inhibition assay	Inhibition of human JAR cell growth in a cell viability assay, IC50=2.6 nM	SANGER
human LoVo cell	Growth inhibition assay	Inhibition of human LoVo cell growth in a cell viability assay, IC50=0.16093 μM	SANGER
human LXF-289 cell	Growth inhibition assay	Inhibition of human LXF-289 cell growth in a cell viability assay, IC50=72.85 nM	SANGER
human MC-IXC cell	Growth inhibition assay	Inhibition of human MC-IXC cell growth in a cell viability assay, IC50=75.33 nM	SANGER
human MDA-MB-231 cell	Growth inhibition assay	Inhibition of human MDA-MB-231 cell growth in a cell viability assay, IC50=0.10807 μM	SANGER
human MDA-MB-361 cell	Growth inhibition assay	Inhibition of human MDA-MB-361 cell growth in a cell viability assay, IC50=0.2264 μM	SANGER
human MDA-MB-453 cell	Growth inhibition assay	Inhibition of human MDA-MB-453 cell growth in a cell viability assay, IC50=0.15188 μM	SANGER
human MG-63 cell	Growth inhibition assay	Inhibition of human MG-63 cell growth in a cell viability assay, IC50=0.11248 μM	SANGER
human NB14 cell	Growth inhibition assay	Inhibition of human NB14 cell growth in a cell viability assay, IC50=76.45 nM	SANGER
human NB7 cell	Growth inhibition assay	Inhibition of human NB7 cell growth in a cell viability assay, IC50=29.28 nM	SANGER
human NCI-H1581 cell	Growth inhibition assay	Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50=67.64 nM	SANGER
human NY cell	Growth inhibition assay	Inhibition of human NY cell growth in a cell viability assay, IC50=0.17762 μM	SANGER
human RKO cell	Growth inhibition assay	Inhibition of human RKO cell growth in a cell viability assay, IC50=15.17 nM	SANGER
human RPMI-2650 cell	Growth inhibition assay	Inhibition of human RPMI-2650 cell growth in a cell viability assay, IC50=0.23831 μM	SANGER
human SAS cell	Growth inhibition assay	Inhibition of human SAS cell growth in a cell viability assay, IC50=33.18 nM	SANGER
human SF126 cell	Growth inhibition assay	Inhibition of human SF126 cell growth in a cell viability assay, IC50=57.07 nM	SANGER
human SK-MEL-30 cell	Growth inhibition assay	Inhibition of human SK-MEL-30 cell growth in a cell viability assay, IC50=37.97 nM	SANGER
human SK-MEL-5 cell	Growth inhibition assay	Inhibition of human SK-MEL-5 cell growth in a cell viability assay, IC50=69.25 nM	SANGER
human SK-UT-1 cell	Growth inhibition assay	Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50=28.68 nM	SANGER
human SW1783 cell	Growth inhibition assay	Inhibition of human SW1783 cell growth in a cell viability assay, IC50=0.21301 μM	SANGER
human SW756 cell	Growth inhibition assay	Inhibition of human SW756 cell growth in a cell viability assay, IC50=0.11236 μM	SANGER
human SW872 cell	Growth inhibition assay	Inhibition of human SW872 cell growth in a cell viability assay, IC50=58.9 nM	SANGER
human SW982 cell	Growth inhibition assay	Inhibition of human SW982 cell growth in a cell viability assay, IC50=0.1107 μM	SANGER
human U-87-MG cell	Growth inhibition assay	Inhibition of human U-87-MG cell growth in a cell viability assay, IC50=82.24 nM	SANGER
human UACC-62 cell	Growth inhibition assay	Inhibition of human UACC-62 cell growth in a cell viability assay, IC50=34.35 nM	SANGER
human YH-13 cell	Growth inhibition assay	Inhibition of human YH-13 cell growth in a cell viability assay, IC50=70.59 nM	SANGER
human YKG-1 cell	Growth inhibition assay	Inhibition of human YKG-1 cell growth in a cell viability assay, IC50=29.76 nM	SANGER

TW-37 {[allProObj[0].p_purity_real_show]}

TW-37 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

TW-37 质控信息

TW-37 生物活性

TW-37 细胞研究

TW-37 参考文献

TW-37 实验方案

TW-37 技术信息

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Bcl-xL	Bcl-xL, Ki:1.11 μM
Mcl-1	Mcl-1, Ki:0.26 μM
Bcl-2	Bcl-2, Ki:0.29 μM

TW-37 {[allProObj[0].p_purity_real_show]}

TW-37 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

TW-37 质控信息

TW-37 生物活性

TW-37 细胞研究

TW-37 参考文献

TW-37 实验方案

TW-37 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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TW-37 纯度/质量文件产品仅供科研