Peiminine, a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq., is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.It induces autophagic cell death thus represses colorectal carcinoma tumor growth.
Peiminine is an alkaloid extracted from the bulb of Fritillaria thunbergii Miq that reportedly has anticancer and anti-inflammatory effects. Peiminine downregulated the levels of specific genes and proteins in vitro and consequently suppressed OC (Osteoclasts) differentiation and function[2]. Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL[3]. Peiminine induced G0/G1-phase arrest, apoptosis, and autophagy in human osteosarcoma cells via the ROS/JNK signaling pathway both in vitro and in vivo[4]. Peiminine (1, 3, or 5 mg/kg) could reduce the W/D ratio and the MPO activity significantly. Furthermore, the histopathological changes and the expression of TNF-α, IL-1β, and IL-6 were inhibited after the peiminine treatment. In vitro, peiminine significantly inhibited LPS-induced IL-8 production in A549 lung epithelial cells[5]. Peiminine suppressed the development of CRC through inhibiting the viability, colony formation and metastasis of CRC (Colorectal cancer) cells via LINC00659/miR-760 axis[6].
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