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Peiminine

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Chemical Structure| 18059-10-4 同义名 : Verticinone;Raddeanine;Sipeimine;Fritillarine;Imperialine;Zhebeinone
CAS号 : 18059-10-4
货号 : A239847
分子式 : C27H43NO3
纯度 : 98+%
分子量 : 429.635
MDL号 : MFCD00210542
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(244.39 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Peiminine is an alkaloid extracted from the bulb of Fritillaria thunbergii Miq that reportedly has anticancer and anti-inflammatory effects. Peiminine downregulated the levels of specific genes and proteins in vitro and consequently suppressed OC (Osteoclasts) differentiation and function[2]. Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL[3]. Peiminine induced G0/G1-phase arrest, apoptosis, and autophagy in human osteosarcoma cells via the ROS/JNK signaling pathway both in vitro and in vivo[4]. Peiminine (1, 3, or 5 mg/kg) could reduce the W/D ratio and the MPO activity significantly. Furthermore, the histopathological changes and the expression of TNF-α, IL-1β, and IL-6 were inhibited after the peiminine treatment. In vitro, peiminine significantly inhibited LPS-induced IL-8 production in A549 lung epithelial cells[5]. Peiminine suppressed the development of CRC through inhibiting the viability, colony formation and metastasis of CRC (Colorectal cancer) cells via LINC00659/miR-760 axis[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.64mL

2.33mL

1.16mL

23.28mL

4.66mL

2.33mL
参考文献

[1]Guo H, Ji F, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10.

[2]Zhu M, Xu W, Jiang J, Wang Y, Guo Y, Yang R, Chang Y, Zhao B, Wang Z, Zhang J, Wang T, Shangguan L, Wang S. Peiminine Suppresses RANKL-Induced Osteoclastogenesis by Inhibiting the NFATc1, ERK, and NF-κB Signaling Pathways. Front Endocrinol (Lausanne). 2021 Sep 24;12:736863

[3]Guo H, Ji F, Liu B, Chen X, He J, Gong J. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10

[4]Yu L, Chen Y, Yuan S, Cao Y, Bi Z. Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo. Front Pharmacol. 2021 Nov 12;12:770846

[5]Du B, Cao L, Wang K, Miu J, Yao L, Xu Z, Song J. Peiminine Attenuates Acute Lung Injury Induced by LPS Through Inhibiting Lipid Rafts Formation. Inflammation. 2020 Jun;43(3):1110-1119

[6]Li J, Qin Y, Wang W, Yang K, Zhang M. Peiminine inhibits the progression of colorectal cancer through up-regulating miR-760 via declining the expression of long noncoding RNA LINC00659. Anticancer Drugs. 2021 Feb 1;32(2):148-156