货号:A626958 同义名: 2-p-tolyl-1,2-Benzisothiazolin-3-one
PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM. PBIT also inhibits JARID1A and JARID1C with IC50 values of 6 and 4.9 μM, respectively[1].
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产品名称 | KDM1 ↓ ↑ | KDM2 ↓ ↑ | KDM3 ↓ ↑ | KDM4 ↓ ↑ | KDM5 ↓ ↑ | KDM6 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OG-L002 |
+++
LSD1, IC50: 20 nM |
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ORY-1001 |
+++
LSD1, IC50: 20 nM |
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SP-2509 |
++++
LSD1, IC50: 13 nM |
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GSK2879552 2HCl |
+
LSD1, Ki: 1.7 μM |
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T-3775440 HCl |
++++
LSD1, IC50: 2.1 nM |
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GSK-LSD1 2HCl |
+++
LSD1, IC50: 16 nM |
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Pulrodemstat benzenesulfonate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IOX1 |
+
KDM2A, IC50: 1.8 μM |
+++
KDM3A, IC50: 0.1 μM |
++
KDM4C, IC50: 0.6 μM KDM4E, IC50: 2.3 μM |
+
KDM5C, IC50: 19 μM |
+
KDM6B, IC50: 1.6 μM |
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PFI-90 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ML324 |
+
JMJD2, IC50: 920 nM |
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NCGC00244536 |
++++
KDM4, IC50: 10 nM |
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KDM4D-IN-1 |
++
KDM4D, IC50: 0.41 μM |
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GSK467 |
++++
KDM5B, Ki: 10 nM |
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GSK-J1 |
+++
JMJD3, IC50: 60 nM |
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(Z)-JIB-04 |
++
JMJD2A, IC50: 1100 nM JMJD2E, IC50: 340 nM |
++
JARID1A, IC50: 230 nM |
++
JMJD3, IC50: 855 nM |
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CPI-455 |
++++
KDM5A, IC50: 10 nM |
++++
KDM5, IC50: 10 nM |
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JIB-04 |
++
JMJD2E, IC50: 435 nM JMJD2D, IC50: 290 nM |
++
JARID1A, IC50: 230 nM |
++
JMJD3, IC50: 855 nM |
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GSK-J4 HCl |
+++
JMJD3, IC50: 60 nM |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | PBIT is a specific inhibitor of JARID1. It inhibits the histone demethylase activity of JARID1B (also known as KDM5B or PLU1), with an IC50 of approximately 3 μM. PBIT also inhibits JARID1A and JARID1C, with IC50 values of 6 μM and 4.9 μM, respectively. PBIT suppresses the proliferation of cells expressing high levels of JARID1B. The inhibition of cell proliferation by PBIT is dependent on the level of JARID1B, specifically at concentrations of 1-10 μM in UACC-812 cells and 2.5-10 μM in MCF7 and MCF10A cells over a period of 72 hours[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.14mL 0.83mL 0.41mL |
20.72mL 4.14mL 2.07mL |
41.44mL 8.29mL 4.14mL |
CAS号 | 2514-30-9 |
分子式 | C14H11NOS |
分子量 | 241.308 |
别名 | 2-p-tolyl-1,2-Benzisothiazolin-3-one |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(207.2 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |