生物活性 | |||
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描述 | PBIT is a specific inhibitor of JARID1. It inhibits the histone demethylase activity of JARID1B (also known as KDM5B or PLU1), with an IC50 of approximately 3 μM. PBIT also inhibits JARID1A and JARID1C, with IC50 values of 6 μM and 4.9 μM, respectively. PBIT suppresses the proliferation of cells expressing high levels of JARID1B. The inhibition of cell proliferation by PBIT is dependent on the level of JARID1B, specifically at concentrations of 1-10 μM in UACC-812 cells and 2.5-10 μM in MCF7 and MCF10A cells over a period of 72 hours[1]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
4.14mL 0.83mL 0.41mL |
20.72mL 4.14mL 2.07mL |
41.44mL 8.29mL 4.14mL |
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