ML324
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货号：A214803
同义名：
CID-44143209
ML324 is an inhibitor of JMJD2 demethylase with IC50 of 920 nM with antiviral activity.
ML324 化学结构
ML324 3D分子结构
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ML324 纯度/质量文件 产品仅供科研
货号：A214803
标准纯度：
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ML324 质控信息
ML324 生物活性
靶点
描述
ML324 is the first potent and cell permeable JMJD2E inhibitor with IC50 value of 920nM. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability. It demonstrated potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression at 50μM. ML324 suppressed the formation of HSV plaques, even at high MOI, and blocked HSV-1 reactivation in a mouse ganglia explant model of latently infected mice[4]
作用机制
ML324 may chelate the active site iron.[4]
ML324 动物研究
Dose
Mice: 0.2 mg/kg[2] [3]
Administration
i.v., i.p.
ML324 参考文献
[1] Rai G, Kawamura A, et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity.
[2] Choi JY, Yoon SS, et al. KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels. Sci Rep. 2017 Mar 22;7:45005.
[3] Wang W, Oguz G, et al. KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer. J Exp Med. 2018 Nov 5;215(11):2833-2849.
[4] Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR, Dexheimer TS, Foley TL, King ON, Quinn A, Mott BT, Schofield CJ, Oppermann U, Jadhav A, Simeonov A, Kristie TM, Maloney DJ. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity. 2012 Dec 17 [updated 2013 Sep 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 24260783.
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ML324 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.86mL
0.57mL
0.29mL
14.31mL
2.86mL
1.43mL
28.62mL
5.72mL
2.86mL
ML324 技术信息
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