OG-L002 | LSD1 Inhibitor | AmBeed-信号通路专用抑制剂

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OG-L002 99%+

货号：A220151

OG-L002 is a selective inhibitor of LSD1 with IC50 of 20 nM.

OG-L002 化学结构
CAS号：1357302-64-7

OG-L002 3D分子结构
CAS号：1357302-64-7

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OG-L002 纯度/质量文件产品仅供科研

货号：A220151 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

组蛋白去甲基酶亚型比较

产品名称	KDM1 ↓ ↑	KDM2 ↓ ↑	KDM3 ↓ ↑	KDM4 ↓ ↑	KDM5 ↓ ↑	KDM6 ↓ ↑	纯度
OG-L002	+++ LSD1, IC50: 20 nM						99%+
ORY-1001	+++ LSD1, IC50: 20 nM						98%
SP-2509	++++ LSD1, IC50: 13 nM						98+%
GSK2879552 2HCl	+ LSD1, Ki: 1.7 μM						99%+
T-3775440 HCl	++++ LSD1, IC50: 2.1 nM						99%
GSK-LSD1 2HCl	+++ LSD1, IC50: 16 nM						98%
Pulrodemstat benzenesulfonate	✔						99%+
IOX1		+ KDM2A, IC50: 1.8 μM	+++ KDM3A, IC50: 0.1 μM	++ KDM4E, IC50: 2.3 μM KDM4C, IC50: 0.6 μM	+ KDM5C, IC50: 19 μM	+ KDM6B, IC50: 1.6 μM	99%
PFI-90			✔				99%+
ML324				+ JMJD2, IC50: 920 nM			99%+
NCGC00244536				++++ KDM4, IC50: 10 nM			95%
KDM4D-IN-1				++ KDM4D, IC50: 0.41 μM			99%+
GSK467					++++ KDM5B, Ki: 10 nM		98%
GSK-J1						+++ JMJD3, IC50: 60 nM	99%+
(Z)-JIB-04				++ JMJD2A, IC50: 1100 nM JMJD2E, IC50: 340 nM	++ JARID1A, IC50: 230 nM	++ JMJD3, IC50: 855 nM	97%
CPI-455					++++ KDM5A, IC50: 10 nM	++++ KDM5, IC50: 10 nM	98%
JIB-04				++ JMJD2E, IC50: 435 nM JMJD2D, IC50: 290 nM	++ JARID1A, IC50: 230 nM	++ JMJD3, IC50: 855 nM	98%
GSK-J4 HCl						+++ JMJD3, IC50: 60 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

OG-L002 生物活性

靶点	KDM1 LSD1, IC50:20 nM
描述	The histone H3K9 demethylase LSD1 plays a critical role in the regulation of herpes simplex virus (HSV) infection. OG-L002 is a selective inhibitor of LSD1 with an IC50 value of 0.02μM. It is also a potent inhibitor of monoamine oxidases (MAO) with IC50 values of 1.38μM and 0.72μM for MAO-A and MAO-B, respectively. OG-L002 inhibited viral immediate-early gene expression in HeLa and HFF cells with IC50 values of ~10µM and ~3µM, respectively. Treatment of Hela cells with 50µM OG-L002 for 24 hours reduced viral yields compared with the DMSO-treated controls. Also in Hela cells, pretreatment with 50µM OG-L002 for 4 hours increased the levels of total histone H3 and H3K9-me2 (20- to 30-fold) associated with viral immediate-early gene promoters. Treatment with OG-L002 (10 - 50µM) for 48 hours repressed viral reactivation in trigeminal ganglia isolated from HSV-infected mice. In BALB/c mice, pretreatment with OG-L002 (6 - 40mg/kg/day) for one week reduced the levels of detectable viral genomes in the ganglia at both 3- and 5-day post-infection. The administration of mice with OG-L002 at a dose of 20mg/kg/day reduced viral genome accumulation at 3-, 5-, and 10-day post-infection^[2].
作用机制	OG-L002 is a potent LSD1 inhibitor that blocks HSV lytic replication and reactivation from latency^[2].

OG-L002 参考文献

[1]Liang Y, Quenelle D, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 2013 Feb 5;4(1):e00558-12.

[2]Liang Y, Quenelle D, Vogel JL, Mascaro C, Ortega A, Kristie TM. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4(1):e00558-12

OG-L002 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.44mL

0.89mL

0.44mL

22.19mL

4.44mL

2.22mL

44.39mL

8.88mL

4.44mL

OG-L002 技术信息

CAS号	1357302-64-7
分子式	C₁₅H₁₅NO
分子量	225.286

别名
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(466.07 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

OG-L002 99%+

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OG-L002 99%+

OG-L002 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

OG-L002 质控信息

OG-L002 生物活性

OG-L002 参考文献

OG-L002 实验方案

OG-L002 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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OG-L002 纯度/质量文件产品仅供科研