左旋甲基多巴 /Methyldopa sesquihydrate
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货号：A789550
同义名：
L-(-)-α-甲基多巴水合物
/ L-(-)-α-Methyldopa hydrate;MK-351 hydrate
Methyldopa sesquihydrate 是一种选择性 α2-肾上腺素能受体激动剂，主要用于治疗高血压。
Methyldopa sesquihydrate 化学结构
Methyldopa sesquihydrate 3D分子结构
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Methyldopa sesquihydrate 纯度/质量文件 产品仅供科研
货号：A789550
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Methyldopa sesquihydrate 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
96%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2B-adrenergic receptor, pKi: 8.9
α2A-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1A-adrenergic receptor, Ki: 3.7 nM
α1D-adrenergic receptor, Ki: 20 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
99%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
99%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Methyldopa sesquihydrate 生物活性
描述
L-(-)-α-Methyldopa hydrate (Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a prodrug and is metabolized in the central nervous system. L-(-)-α-Methyldopa hydrate (200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. L-alpha-Methyldopa also reduced (49%) the dieldrin-effected increase in hepatic PEPCK (phosphoenolpyruvate carboxykinase) activity[2]
Methyldopa sesquihydrate 参考文献
Methyldopa sesquihydrate 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.10mL
0.42mL
0.21mL
10.49mL
2.10mL
1.05mL
20.99mL
4.20mL
2.10mL
Methyldopa sesquihydrate 技术信息
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