Methyldopa sesquihydrate

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Chemical Structure| 41372-08-1 同义名 : L-(-)-α-甲基多巴水合物 ;L-(-)-α-Methyldopa hydrate;MK-351 hydrate
CAS号 : 41372-08-1
货号 : A789550
分子式 : C20H32N2O11
纯度 : 98%
分子量 : 476.475
MDL号 : MFCD00149280
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(52.47 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.1 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 L-(-)-α-Methyldopa hydrate (Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a prodrug and is metabolized in the central nervous system. L-(-)-α-Methyldopa hydrate (200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. L-alpha-Methyldopa also reduced (49%) the dieldrin-effected increase in hepatic PEPCK (phosphoenolpyruvate carboxykinase) activity[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.49mL

2.10mL

1.05mL

20.99mL

4.20mL

2.10mL
参考文献

[1]BAILA MR, CINTAS JA. The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension. Dia Med. 1962 Dec 6;34:2422-4.

[2]Fox GR, Virgo BB. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985 May;78(3):342-50