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氯苄氨胍醋酸盐 /Guanabenz Acetate {[allProObj[0].p_purity_real_show]}

货号:A461798 同义名: Wy8678 acetate;BR-750

Guanabenz Acetate是一种中枢作用的 α-2 肾上腺素能受体激动剂,用作抗高血压药物治疗高血压。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Guanabenz Acetate 化学结构 CAS号:23256-50-0
Guanabenz Acetate 化学结构
CAS号:23256-50-0
Guanabenz Acetate 3D分子结构
CAS号:23256-50-0
Guanabenz Acetate 化学结构 CAS号:23256-50-0
Guanabenz Acetate 3D分子结构 CAS号:23256-50-0
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Guanabenz Acetate 纯度/质量文件 产品仅供科研

货号:A461798 标准纯度: {[allProObj[0].p_purity_real_show]}
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Guanabenz Acetate 生物活性

描述 Guanabenz Acetate is an alpha2 adrenergic receptor agonist shown to interact with a regulatory subunit of the protein phosphatase, Pp1/Gadd34, and selectively disrupt the dephosphorylation of the alpha subunit of eukaryotic initiation factor 2.Guanabenz treatment accelerated ALS-like disease progression in a strain of mutant SOD1 transgenic ALS(Amyotrophic Lateral Sclerosis) mice[3]. Guanabenz Acetate is capable of markedly increasing the cellular internalization and target mRNA silencing of hydrophobically modified siRNAs (hsiRNAs), yielding a ∼100-fold decrease in hsiRNA IC50 (from 132 nM to 2.4 nM)[4].

Guanabenz Acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02423083 Multiple Sclerosis, Relapsing-... 展开 >>Remitting Multiple Sclerosis 收起 << Phase 1 Terminated - United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT02443103 Bone Cancer M... 展开 >>etastasis 收起 << Not Applicable Terminated(Slow accrual) - United States, Indiana ... 展开 >> Indiana University Health Hospital Indianapolis, Indiana, United States, 46202 Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 Sidney & Lois Eskenazi Hospital Indianapolis, Indiana, United States, 46202 Spring Mill Medical Center Indianapolis, Indiana, United States, 46290 收起 <<
NCT02443103 - Terminated(Slow accrual) - -

Guanabenz Acetate 参考文献

[1]Noguchi S, Jianmongkol S, et al. Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric-oxide synthase. J Biol Chem. 2000 Jan 28;275(4):2376-80.

[2]Jasper JR, Lesnick JD, et al. Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S] GTPgammaS binding. Biochem Pharmacol. 1998 Apr 1;55(7):1035-43.

[3]Vieira FG, Ping Q, Moreno AJ, Kidd JD, Thompson K, Jiang B, Lincecum JM, Wang MZ, De Zutter GS, Tassinari VR, Levine B, Hatzipetros T, Gill A, Perrin S. Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS. PLoS One. 2015 Aug 19;10(8):e0135570.

[4] Osborn MF, Alterman JF, Nikan M, Cao H, Didiot MC, Hassler MR, Coles AH, Khvorova A. Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs. Nucleic Acids Res. 2015 Oct 15;43(18):8664-72.

Guanabenz Acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.17mL

3.43mL

1.72mL

34.35mL

6.87mL

3.43mL

Guanabenz Acetate 技术信息

CAS号23256-50-0
分子式C10H12Cl2N4O2
分子量 291.134
别名 Wy8678 acetate;BR-750
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 50 mg/mL(171.74 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(8.59 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方

4% DMSO+30% PEG 300+water 5 mg/mL

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