Guanabenz Acetate
产品说明书
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同义名 : | Wy8678 acetate;BR-750 |
| CAS号 : | 23256-50-0 | |
| 货号 : | A461798 | |
| 分子式 : | C10H12Cl2N4O2 | |
| 纯度 : | 99% | |
| 分子量 : | 291.134 | |
| MDL号 : | MFCD00153801 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(171.74 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 2.5 mg/mL(8.59 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
4% DMSO+30% PEG 300+water 5 mg/mL |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Guanabenz Acetate is an alpha2 adrenergic receptor agonist shown to interact with a regulatory subunit of the protein phosphatase, Pp1/Gadd34, and selectively disrupt the dephosphorylation of the alpha subunit of eukaryotic initiation factor 2.Guanabenz treatment accelerated ALS-like disease progression in a strain of mutant SOD1 transgenic ALS(Amyotrophic Lateral Sclerosis) mice[3]. Guanabenz Acetate is capable of markedly increasing the cellular internalization and target mRNA silencing of hydrophobically modified siRNAs (hsiRNAs), yielding a ∼100-fold decrease in hsiRNA IC50 (from 132 nM to 2.4 nM)[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02423083 | Multiple Sclerosis, Relapsing-... 展开 >>Remitting Multiple Sclerosis 收起 << | Phase 1 | Terminated | - | United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 << |
| NCT02443103 | Bone Cancer M... 展开 >>etastasis 收起 << | Not Applicable | Terminated(Slow accrual) | - | United States, Indiana ... 展开 >> Indiana University Health Hospital Indianapolis, Indiana, United States, 46202 Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 Sidney & Lois Eskenazi Hospital Indianapolis, Indiana, United States, 46202 Spring Mill Medical Center Indianapolis, Indiana, United States, 46290 收起 << |
| NCT02443103 | - | Terminated(Slow accrual) | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.43mL 0.69mL 0.34mL |
17.17mL 3.43mL 1.72mL |
34.35mL 6.87mL 3.43mL |
| 参考文献 |
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