光甘草定 /Glabridin
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货号：A458176
同义名：
Q-100692;KB-289522
Glabridin 是一种天然产物，从甘草根部提取和纯化，具有多种生物学功能，如在高葡萄糖水平下调节iNOS的合成和活性，显著抑制代谢中产生的自由基，保护抗氧化敏感的生物大分子（如LDL、DNA）和细胞壁，具有美白和抗衰老活性。
Glabridin 化学结构
Glabridin 3D分子结构
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Glabridin 纯度/质量文件 产品仅供科研
货号：A458176
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Glabridin 质控信息
Glabridin 生物活性
描述
Glabridin, a compound in the root extract of Glycyrrhiza glabra, as an effective tyrosinase inhibitor. Glabridin applied on skin can inhibit melanin synthesis[3] [6] [7] [5] [8]
Glabridin 参考文献
[1] Yehuda I, Madar Z, et al. Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation. Mol Nutr Food Res. 2015 Jun;59(6):1041-52.
[2] Hsieh MJ, Lin CW, et al. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 2014 Jun;171(12):3037-50.
[3] Hespeler D, Kaltenbach J, Pyo SM. Glabridin smartPearls - Silica selection, production, amorphous stability and enhanced solubility. Int J Pharm. 2019 Apr 20;561:228-235. doi: 10.1016/j.ijpharm.2019.02.028. Epub 2019 Mar 2. PMID: 30836152.
[4] Li LJ, Li GW, Xie Y. Zhongguo Zhong Yao Za Zhi. 2019;44(17):3786-3791.
[5] Mu J, Zhu D, Shen Z, Ning S, Liu Y, Chen J, Li Y, Li Z. The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin-induced anti-angiogenesis in human breast cancer cells. BMC Cancer. 2017 May 2;17(1):307. doi: 10.1186/s12885-017-3298-1. PMID: 28464803; PMCID: PMC5414299.
[6] Hsieh MJ, Lin CW, Yang SF, Chen MK, Chiou HL. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 2014 Jun;171(12):3037-50. doi: 10.1111/bph.12626. Erratum in: Br J Pharmacol. 2017 May;174(9):909-910. PMID: 24641665; PMCID: PMC4055204.
[7] Huang HL, Hsieh MJ, Chien MH, Chen HY, Yang SF, Hsiao PC. Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. PLoS One. 2014 Jun 5;9(6):e98943. doi: 10.1371/journal.pone.0098943. PMID: 24901249; PMCID: PMC4047044.
[8] Kwon HS, Oh SM, Kim JK. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clin Exp Immunol. 2008 Jan;151(1):165-73. doi: 10.1111/j.1365-2249.2007.03539.x. Epub 2007 Nov 14. PMID: 18005263; PMCID: PMC2276918.
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Glabridin 实验方案
计算器
摩尔计算器
总药量计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.08mL
0.62mL
0.31mL
15.41mL
3.08mL
1.54mL
30.83mL
6.17mL
3.08mL
Glabridin 技术信息
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