Glabridin

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Chemical Structure| 59870-68-7 同义名 : Q-100692;KB-289522;LS-176045
CAS号 : 59870-68-7
货号 : A458176
分子式 : C20H20O4
纯度 : 99%+
分子量 : 324.37
MDL号 : MFCD03427694
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(77.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Glabridin, a compound in the root extract of Glycyrrhiza glabra, as an effective tyrosinase inhibitor. Glabridin applied on skin can inhibit melanin synthesis[3]. Glabridin significantly inhibited migration/invasion capacities of HCC cells, Huh7 and Sk-Hep-1[6]. Glabridin-induced cell apoptosis in HL-60 and MV4-11 cells[7]. Glabridin also upregulated the expression of miR-148a in a dose-dependent manner and attenuated angiogenesis in two human breast cancer cell lines (MDA-MB-231 and Hs-578T)[5]. Glabridin((10 or 50 mg/kg/day) ) could ameliorate dextran sulphate sodium (DSS)-induced colitis[8].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL
参考文献

[1]Yehuda I, Madar Z, et al. Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation. Mol Nutr Food Res. 2015 Jun;59(6):1041-52.

[2]Hsieh MJ, Lin CW, et al. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 2014 Jun;171(12):3037-50.

[3]Hespeler D, Kaltenbach J, Pyo SM. Glabridin smartPearls - Silica selection, production, amorphous stability and enhanced solubility. Int J Pharm. 2019 Apr 20;561:228-235. doi: 10.1016/j.ijpharm.2019.02.028. Epub 2019 Mar 2. PMID: 30836152.

[4]Li LJ, Li GW, Xie Y. Zhongguo Zhong Yao Za Zhi. 2019;44(17):3786-3791.

[5]Mu J, Zhu D, Shen Z, Ning S, Liu Y, Chen J, Li Y, Li Z. The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin-induced anti-angiogenesis in human breast cancer cells. BMC Cancer. 2017 May 2;17(1):307. doi: 10.1186/s12885-017-3298-1. PMID: 28464803; PMCID: PMC5414299.

[6]Hsieh MJ, Lin CW, Yang SF, Chen MK, Chiou HL. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 2014 Jun;171(12):3037-50. doi: 10.1111/bph.12626. Erratum in: Br J Pharmacol. 2017 May;174(9):909-910. PMID: 24641665; PMCID: PMC4055204.

[7]Huang HL, Hsieh MJ, Chien MH, Chen HY, Yang SF, Hsiao PC. Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. PLoS One. 2014 Jun 5;9(6):e98943. doi: 10.1371/journal.pone.0098943. PMID: 24901249; PMCID: PMC4047044.

[8]Kwon HS, Oh SM, Kim JK. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clin Exp Immunol. 2008 Jan;151(1):165-73. doi: 10.1111/j.1365-2249.2007.03539.x. Epub 2007 Nov 14. PMID: 18005263; PMCID: PMC2276918.