吉非罗齐 /Gemfibrozil
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货号：A640007
同义名：
CI-719
Gemfibrozil 是PPARα的激动剂，可作为高脂血症药物，提高血浆HDL并降低三酰甘油。
Gemfibrozil 化学结构
Gemfibrozil 3D分子结构
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Gemfibrozil 纯度/质量文件 产品仅供科研
货号：A640007
标准纯度：
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产品说明书
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Gemfibrozil 质控信息
Gemfibrozil 生物活性
描述
PPAR (peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of PPARα, PPARγ, and PPARβ/δ[3] [4] [5] [6]
Gemfibrozil 参考文献
[1] Pahan K, Jana M, et al. Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002;277(48):45984-91
[2] Prueksaritanont T, Zhao JJ, et al. Mechanistic studies on metabolic interactions between gemfibrozil and statins. J Pharmacol Exp Ther. 2002 Jun;301(3):1042-51.
[3] Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S. The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases. J Adv Pharm Technol Res. 2011 Oct;2(4):236-40.
[4] Kim NJ, Lee KO, Koo BW, et al. Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARalpha/gamma dual agonists. Bioorg Med Chem Lett. 2007;17(13):3595-3598.
[5] Solanki YB, Jain SM. Antihyperlipidemic activity of Clitoria ternatea and Vigna mungo in rats. Pharm Biol. 2010;48(8):915-923.
[6] Calkin AC, Cooper ME, Jandeleit-Dahm KA, Allen TJ. Gemfibrozil decreases atherosclerosis in experimental diabetes in association with a reduction in oxidative stress and inflammation. Diabetologia. 2006;49(4):766-774.
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Gemfibrozil 实验方案
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摩尔计算器
总药量计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.99mL
0.80mL
0.40mL
19.97mL
3.99mL
2.00mL
39.95mL
7.99mL
3.99mL
Gemfibrozil 技术信息
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