GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively.
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产品名称 | ALK ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ASP3026 |
+
ALK, IC50: 3.5 nM |
99%+ | |||||||||||||||||
ALK-IN-1 |
++++
ALK, IC50: 0.07 nM |
99%+ | |||||||||||||||||
Crizotinib |
++++
ROS1, Ki: <0.025 nM ALK, IC50: 24 nM |
99%+ | |||||||||||||||||
Entrectinib | ✔ | 99%+ | |||||||||||||||||
Brigatinib |
+++
ALK, IC50: 0.37 nM ROS1, IC50: 1.9 nM |
FLT3 | 98% | ||||||||||||||||
NVP-TAE 684 |
+
ALK, IC50: 3 nM |
99%+ | |||||||||||||||||
Alectinib |
++
ALK (F1174L), IC50: 3.5 nM ALK, IC50: 1.9 nM |
98% | |||||||||||||||||
Ceritinib |
+++
ALK, IC50: 0.2 nM |
Insulin Receptor,IGF-1R | 98% | ||||||||||||||||
GSK1838705A |
+++
ALK, IC50: 0.5 nM |
Insulin Receptor,IGF-1R | 99% | ||||||||||||||||
AZD-3463 |
++
ALK, Ki: 0.75 nM |
IGF-1R | 99% | ||||||||||||||||
Lorlatinib |
++++
ROS1, Ki: <0.07 nM ALK (L1196M), Ki: 0.07 nM |
98% | |||||||||||||||||
Repotrectinib |
+
ALK(L1196M), IC50: 1.01 nM ALK(G1202R), IC50: 1.26 nM |
Src | 99% | ||||||||||||||||
Belizatinib |
++
ALK, IC50: 0.7 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | IGF-1R ↓ ↑ | Insulin Receptor ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BMS-536924 |
++
IGF-1R, IC50: 100 nM |
+++
Insulin Receptor, IC50: 73 nM |
FAK,MEK | 98% | |||||||||||||||
GSK1904529A |
+++
IGF-1R, IC50: 27 nM |
+++
Insulin Receptor, IC50: 25 nM |
98+% | ||||||||||||||||
Picropodophyllin |
++++
IGF-1R, IC50: 1 nM |
99%+ | |||||||||||||||||
NVP-AEW541 |
++
IGF-1R, IC50: 0.15 μM |
++
Insulin Receptor, IC50: 0.14 μM |
FLT3 | 99%+ | |||||||||||||||
NVP-ADW742 |
+
IGF-1R, IC50: 0.17 μM |
99% | |||||||||||||||||
GSK1838705A |
+++
IGF-1R, IC50: 2 nM |
++++
Insulin Receptor, IC50: 1.6 nM |
ALK | 99% | |||||||||||||||
BMS-754807 |
++++
IGF-1R, IC50: 1.8 nM |
++++
Insulin Receptor, IC50: 1.7 nM |
99%+ | ||||||||||||||||
Linsitinib |
+++
IGF-1R, IC50: 35 nM |
++
Insulin Receptor, IC50: 75 nM |
99%+ | ||||||||||||||||
AG1024 |
+
IGF-1R, IC50: 7 μM |
+
Insulin Receptor, IC50: 57 μM |
98% | ||||||||||||||||
PQ401 |
+
IGF-1R, IC50: <1 μM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.88mL 0.38mL 0.19mL |
9.39mL 1.88mL 0.94mL |
18.78mL 3.76mL 1.88mL |
CAS号 | 1116235-97-2 |
分子式 | C27H29FN8O3 |
分子量 | 532.569 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(197.16 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |