There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
IGF-1R (insulin-like growth factor-1 receptor) plays a key role in transformation, growth and survival of malignant cells, and has been considered as a general and promising target for cancer treatment. Picropodophyllin is a highly specific IGF-1R receptor with IC50 value of 1nM, even does not exhibit inhibition on phosphorylation of IR, a highly homologous receptor of IGF-1R, in cells. Picropodophyllin dose dependently blocked autophosphorylation of IGF-1R induced by IGF-1, as well as its downstream AKT and ERK on phosphorylation level in P6 cells treated with Picropodophyllin at concentration ranging in 0.5-10μM for 1h after 20 hour starvation, and cell apoptosis could be observed after treatment with 0.5μM Picropodophyllin for 6h. Growth inhibition by Picropodophyllin can be observed in a panel of tumor cells from various tumor types with IC50 values≤50nM, including FM 55, SK-MEL-28, SK-MEL-5, C8161, DFB, DFW, AA (melanoma), RD-ES (sarcoma), MCF 7 (breast carcinoma), PC3 (prostate carcinoma), HepG2 (hepatoma), P6 (embryonic mouse fibroblasts) cell lines. Administration of Picropodophyllin (20mg/kg/12h) for 8-14 days blocked growth of IGF-1R-positive tumors and caused complete regression in mice xenograft model of ES-1, BE and PC3[1].
作用机制
Picropodophyllin may inhibit IGF-1R autophosphorylation at the substrate level, not ATP-competitive.[1]
Picropodophyllin 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
A-549 (human lung carcinoma) neoplastic cell line
Cytotoxic assay
In vitro cytotoxicity against the A-549 (human lung carcinoma) neoplastic cell line, IC50=60 nM
14980682
HT-29 (human colon carcinoma) neoplastic cell line
Cytotoxic assay
In vitro cytotoxicity against the HT-29 (human colon carcinoma) neoplastic cell line, IC50=60 nM
14980682
P-388 neoplastic cell line
Cytotoxic assay
In vitro cytotoxicity against the P-388 (from DBA/2 mouse) neoplastic cell line, IC50=60 nM
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