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GSK1838705A

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Chemical Structure| 1116235-97-2 同义名 : -
CAS号 : 1116235-97-2
货号 : A668167
分子式 : C27H29FN8O3
纯度 : 99%
分子量 : 532.569
MDL号 : MFCD19443644
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(197.16 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • IGF-1R

    IGF-1R, IC50:2 nM

  • Insulin Receptor

    Insulin Receptor, IC50:1.6 nM

  • ALK

    ALK, IC50:0.5 nM
描述 GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.39mL

1.88mL

0.94mL

18.78mL

3.76mL

1.88mL
参考文献

[1]Zhou X, Shen F, et al. GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo. Mol Med Rep. 2015 Oct;12(4):5641-6.

[2]Sabbatini P, Korenchuk S, et al. GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20.