Insulin degludec是一种超长效胰岛素，能够持续稳定地降低血糖水平，用于糖尿病管理研究。

D-(+)-Sorbose是一种D-山梨糖的活性对映异构体，能够有效抑制双糖酶活性，并减少大鼠餐后血糖和胰岛素水平，具有防治2型糖尿病等代谢性疾病的潜力。

Peonidin 3-O-glucoside chloride是一种花青素类化合物，能够作为胰岛素促分泌剂，促进HepG2细胞对葡萄糖的摄取。该化合物在2型糖尿病及其并发症的研究中具有潜在应用价值。

Ceritinib D7是一种选择性、口服有效且具有ATP竞争性的ALK酪氨酸激酶抑制剂，适用于ALK相关的癌症治疗研究。

Tolazamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity.

MSDC-0160 is a prototype mTOR-modulating insulin sensitizer being studied to treat diabetes and Alzheimer's disease.

Ceritinib（LDK378）是一种选择性、口服可用的、ATP竞争性的ALK酪氨酸激酶抑制剂，IC50为200 pM。Ceritinib（LDK378）还以8、7和23 nM的IC50值抑制IGF-1R、InsR和STK22D。Ceritinib（LDK378）显示出强大的抗肿瘤活性。

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.

Linsitinib（OSI-906）是一种高效、选择性和口服可用的IGF-1受体和胰岛素受体（IR）的双重抑制剂，IC50分别为35 nM和75 nM。

NVP-AEW541 (AEW541) 是一种口服活性的胰岛素样生长因子 1 受体 (IGF-1R) 抑制剂，IC50 为 0.15 μM。它还抑制胰岛素受体 (InsR)，IC50 为 0.14 μM，显示出显著的抗肿瘤活性。

Cinnamic acid can stimulate insulin secretion and improve glucose tolerance.

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc.

Rhoifolin, a natural product isolated and purified from the leaves of Turpinia arguya Seem, hows monolithic proliferation inhibitory activities against Hela, A549 and MCF-7 cell lines, and may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4. It was found to efficiently block the enzymatic activity of SARS-CoV 3CLpro.

Kaempferitrin can activate insulin signaling pathway, phosphorylate Akt kinase and exert the transloocation of GLUT4, thus has antitumor, antidepressant and antidiabetic effects. Kaempferitrin is a natural product isolated and purified from the root of Kaempferia galangal L..

Gastric Inhibitory Peptide (GIP), human is thought to act as an inhibitor of gastric functions. It also affects lipid metabolism and displays mitogenic and antiapoptotic effects in pancreatic β-cells.