There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Fenbendazole-d3, which is a deuterium-labeled variant of Fenbendazole, acts as a HIF-1α agonist, particularly affecting the HIF-1α-related GLUT1 pathway. Fenbendazole itself is an orally active benzimidazole anthelmintic agent known for its broad-spectrum antiparasitic activity. It is also identified as a microtubule destabilizing agent, capable of inducing cell-cycle arrest and mitotic cell death, demonstrating antitumor efficacy in mouse models xenografted with wild-type p53[1].[2].[3].[4].
体外研究
In vitro, Fenbendazole-d3 at a concentration of 20 µM over 48 hours has shown to counteract the effects of miR-143-5p on cell proliferation, colony-forming capacity, and migration[1].
At a concentration of 10 µM for 48 hours, Fenbendazole-d3 increases the protein expression levels of HIF-1α and GLUT1, thereby enhancing glucose transport and potentially contributing to its antitumor activity[1].
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HazMat Fee +
