货号:A1213143 同义名: Methyl 5-(phenylthio)-2-benzimidazolecarbamate-d3
Fenbendazole-d3是氘标记的 Fenbendazole,可作为 HIF-1α 激动剂,激活与 HIF-1α 相关的 GLUT1 通路。Fenbendazole 是一种具有广泛抗寄生虫活性的口服活性苯并咪唑驱虫剂,同时也是一种微管去稳定剂。Fenbendazole 能导致细胞周期停滞和有丝分裂细胞死亡,并在野生型 p53 异种移植小鼠中展现抗肿瘤活性。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | HIF ↓ ↑ | HIF1 ↓ ↑ | PHD1 ↓ ↑ | PHD2 ↓ ↑ | PHD3 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
KC7F2 |
+
HIF-1α, IC50: 20 μM |
+
HIF-1α, IC50: 20 μM |
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Lificiguat | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
BAY 87-2243 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PX-478·2HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
2-Methoxyestradiol | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CAY10585 |
++
HIF, IC50: 4.4 μM |
BCRP | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
DMOG | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
FG 2216 |
++
PHD2, IC50: 3.9 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
MK-8617 |
++++
PHD1, IC50: 1 nM |
++++
PHD2, IC50: 1 nM |
++++
PHD3, IC50: 14 nM |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Fenbendazole-d3, which is a deuterium-labeled variant of Fenbendazole, acts as a HIF-1α agonist, particularly affecting the HIF-1α-related GLUT1 pathway. Fenbendazole itself is an orally active benzimidazole anthelmintic agent known for its broad-spectrum antiparasitic activity. It is also identified as a microtubule destabilizing agent, capable of inducing cell-cycle arrest and mitotic cell death, demonstrating antitumor efficacy in mouse models xenografted with wild-type p53[1].[2].[3].[4]. |
体外研究 | In vitro, Fenbendazole-d3 at a concentration of 20 µM over 48 hours has shown to counteract the effects of miR-143-5p on cell proliferation, colony-forming capacity, and migration[1]. At a concentration of 10 µM for 48 hours, Fenbendazole-d3 increases the protein expression levels of HIF-1α and GLUT1, thereby enhancing glucose transport and potentially contributing to its antitumor activity[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.31mL 0.66mL 0.33mL |
16.54mL 3.31mL 1.65mL |
33.07mL 6.61mL 3.31mL |
CAS号 | 1228182-47-5 |
分子式 | C15H13N3O2S |
分子量 | 302.36 |
别名 | Methyl 5-(phenylthio)-2-benzimidazolecarbamate-d3 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 4 mg/mL(13.23 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |