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缺氧诱导因子抑制剂
/ DMOG

二甲基草酰甘氨酸 /DMOG 98%

货号：A160647 同义名： Dimethyloxallyl Glycine;Dimethyloxalylglycine Ambeed 开学季，买赠积分，赢豪礼

DMOG 是一种 HIF-1α 稳定剂，能够抑制 HIF-1α 的降解。DMOG 主要用于缺氧反应、血管生成和癌症的研究。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
DMOG 化学结构 CAS号：89464-63-1
DMOG 化学结构
CAS号：89464-63-1
DMOG 3D分子结构
CAS号：89464-63-1
DMOG 化学结构 CAS号：89464-63-1
DMOG 3D分子结构 CAS号：89464-63-1
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DMOG 纯度/质量文件 产品仅供科研

货号：A160647 标准纯度： 98%
批次查询： 批次纯度:

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产品名称 HIF ↓ HIF1 ↓ PHD1 ↓ PHD2 ↓ PHD3 ↓ 其他靶点 纯度
KC7F2 +

HIF-1α, IC50: 20 μM

 		+

HIF-1α, IC50: 20 μM

 		98%
Lificiguat ✔ 99%+
BAY 87-2243 ✔ 99%+
PX-478·2HCl ✔ 98%+
2-Methoxyestradiol ✔ 98%
CAY10585 ++

HIF, IC50: 4.4 μM

 		BCRP 97%
DMOG ✔ 98%
FG 2216 ++

PHD2, IC50: 3.9 μM

 		99%+
MK-8617 ++++

PHD1, IC50: 1 nM

 		++++

PHD2, IC50: 1 nM

 		++++

PHD3, IC50: 14 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

DMOG 生物活性

靶点

  • PHD1

  • Hydroxylase
描述 The family of HIF-PH (HIF prolyl hydroxylase) enzymes are the main molecular to regulate HIF activity through hydroxylation at 2 proline residues and cause the degradation of HIF, thus leading to inhibition on accumulation of functional HIF under normoxia. DMOG (Dimethyloxalylglycine) is a prolyl 4-hydroxylase inhibitor with IC50 value of 2 μM (measured by hydroxyproline formation in chicken embryo calvaria) [1]. HIF-1α is strongly induced in Hep3B and U2OS cells exposure to 100 μM or 1000 μM DMOG for 6h under normoxic culture conditions[2]. Administration to newborn pups by i.p. injections at a dose of 200 mg/kg DMOG conferred a protective phenotype in the retinopathy of prematurity (ROP) model[3].
作用机制 DMOG, an analog to 2OG, can inhibit prolyl 4-hydroxylase in a competitive manner[4]. It is the most structurally basic 2OG-derived HIF stabilizer[3].

DMOG 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
human 293T cells 2.5 mM Function assay Inhibition of JMJD2-mediated H3K36 demethylation in human 293T cells at 2.5 mM 19359167
human A3-KAW cell Growth inhibition assay Inhibition of human A3-KAW cell growth in a cell viability assay, IC50=15.8174 μM SANGER
human A4-Fuk cell Growth inhibition assay Inhibition of human A4-Fuk cell growth in a cell viability assay, IC50=45.0364 μM SANGER
human BEN cell Growth inhibition assay Inhibition of human BEN cell growth in a cell viability assay, IC50=36.8187 μM SANGER

DMOG 动物研究

Dose Mice: 8 mg/Mice[5] (i.p.); 20 mg/kg - 100 mg/kg[6] (i.p.)
Administration i.p.

DMOG 参考文献

[1]Baader E, Tschank G, et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 ( Pt 2):525-30.

[2]Jaakkola P, Mole DR, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001 Apr 20;292(5516):468-72. Epub 2001 Apr 5.

[3]Hoppe G, Yoon S, et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity. Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2516-25.

[4]Cunliffe CJ, Franklin TJ, et al. Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives. J Med Chem. 1992 Jul 10;35(14):2652-8.

[5]Yang N, Wei Y, et al. Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra. Sci Rep. 2016 Jul 6;6:28933.

[6]Hams E, Saunders SP, et al. The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock. 2011 Sep;36(3):295-302.

DMOG 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.71mL

1.14mL

0.57mL

28.55mL

5.71mL

2.85mL

57.10mL

11.42mL

5.71mL

DMOG 技术信息

CAS号89464-63-1
分子式C6H9NO5
分子量 175.139
别名 Dimethyloxallyl Glycine;Dimethyloxalylglycine;Dimethyloxaloylglycine
运输蓝冰
存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(599.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(285.49 mM)，配合低频超声助溶
动物实验配方

Tags: DMOG | Dimethyloxallyl Glycine;Dimethyloxalylglycine;Dimethyloxaloylglycine | Hypoxia Inducible Factor (HIF) Inhibitor | HIF | AmBeed-信号通路专用抑制剂 | DMOG 纯度/质量文件 | DMOG 亚型比较 | DMOG 生物活性 | DMOG 细胞研究 | DMOG 动物研究 | DMOG 参考文献 | DMOG 实验方案 | DMOG 技术信息

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