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Fenbendazole-d3

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Chemical Structure| 1228182-47-5 同义名 : Methyl 5-(phenylthio)-2-benzimidazolecarbamate-d3
CAS号 : 1228182-47-5
货号 : A1213143
分子式 : C15H13N3O2S
纯度 : 98% 98%atom%D
分子量 : 302.36
MDL号 : MFCD16652570
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(13.23 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Fenbendazole-d3, which is a deuterium-labeled variant of Fenbendazole, acts as a HIF-1α agonist, particularly affecting the HIF-1α-related GLUT1 pathway. Fenbendazole itself is an orally active benzimidazole anthelmintic agent known for its broad-spectrum antiparasitic activity. It is also identified as a microtubule destabilizing agent, capable of inducing cell-cycle arrest and mitotic cell death, demonstrating antitumor efficacy in mouse models xenografted with wild-type p53[1].[2].[3].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.07mL

6.61mL

3.31mL
参考文献

[1]Jia Xu, et al. miR-143-5p suppresses breast cancer progression by targeting the HIF-1α-related GLUT1 pathway. Oncol Lett. 2022 May;23(5):147.

[2]Nilambra Dogra, et al. Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Sci Rep. 2018 Aug 9;8(1):11926.

[3]Hossein Aleyasin, et al. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. Antioxid Redox Signal. 2015 Jan 10;22(2):121-34.

[4]Qiwen Duan, et al. Fenbendazole as a potential anticancer drug. Anticancer Res. 2013 Feb;33(2):355-62.