Curcumenol inhibitsNF-κB activation by suppressing the nuclear translocation of theNF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
Curcumenol is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities[2]. Curcumenol also remarkably enhanced myogenic differentiation and mitochondrial function[3]. Curcumenol diminishes the proinflammatory mediators and the expression of the regulatory genes in LPS-stimulated BV-2 by inhibiting Akt-dependent NF-κB activation and downregulation of Akt and p38 MAPKs signaling[4]. Curcumenol mitigated inflammation in ATDC5 chondrocytes and primary mice chondrocytes, and also ameliorated OA (osteoarthritis) in a DMM(destabilization of medial meniscus)‑induced mouse model[5].
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