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Curcumenol

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Chemical Structure| 19431-84-6 同义名 : 莪术醇 ;(+)-Curcumenol
CAS号 : 19431-84-6
货号 : A767094
分子式 : C15H22O2
纯度 : 98%
分子量 : 234.334
MDL号 : MFCD01729508
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(512.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Curcumenol is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities[2]. Curcumenol also remarkably enhanced myogenic differentiation and mitochondrial function[3]. Curcumenol diminishes the proinflammatory mediators and the expression of the regulatory genes in LPS-stimulated BV-2 by inhibiting Akt-dependent NF-κB activation and downregulation of Akt and p38 MAPKs signaling[4]. Curcumenol mitigated inflammation in ATDC5 chondrocytes and primary mice chondrocytes, and also ameliorated OA (osteoarthritis) in a DMM(destabilization of medial meniscus)‑induced mouse model[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.27mL

0.85mL

0.43mL

21.34mL

4.27mL

2.13mL

42.67mL

8.54mL

4.27mL
参考文献

[2]Sun DX, Fang ZZ, Zhang YY, Cao YF, Yang L, Yin J. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6

[3]Zhang LS , Shen SN , Gao YL , Shi SY , Zhou CX , Mo JX , Xu YK , Lin LG , Gan LS . Tautomerism and bioactivities of curcumenol, a common sesquiterpenoid widely existing in edible plants. Food Funct. 2019 Mar 20;10(3):1288-1294

[4]Lo JY, Kamarudin MN, Hamdi OA, Awang K, Kadir HA. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9

[5]Yang X, Zhou Y, Chen Z, Chen C, Han C, Li X, Tian H, Cheng X, Zhang K, Zhou T, Zhao J. Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. Int J Mol Med. 2021 Oct;48(4):192