CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].
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产品名称 | PPARα ↓ ↑ | PPARβ/δ ↓ ↑ | PPARγ ↓ ↑ | PPARδ ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fenofibric acid | ✔ | 98% | |||||||||||||||||
GW6471 |
++
PPARα, IC50: 0.24 μM |
99%+ | |||||||||||||||||
GSK3787 |
++
PPARδ, pIC50: 6.6 |
++
PPARδ, pIC50: 6.6 |
99%+ | ||||||||||||||||
FH535 | ✔ | 98%+ | |||||||||||||||||
GW9662 |
+++
PPARα, IC50: 32 nM |
+++
PPARγ, IC50: 3.3 nM |
98% | ||||||||||||||||
T0070907 |
++++
PPARγ, IC50: 1 nM |
98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | CUDA is a potent inhibitor of sEH with an IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1].CUDA selectively enhances peri-PPARα activity and functions as a PPARα ligand, i.e., it competitively inhibits the binding of Wy-14643 to the PPARα ligand binding domain. At a concentration of 10 μM for 18 hours, CUDA increased PPARα activity in COS-7 cells by 6-fold and 3-fold, respectively[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.94mL 0.59mL 0.29mL |
14.68mL 2.94mL 1.47mL |
29.37mL 5.87mL 2.94mL |
CAS号 | 479413-68-8 |
分子式 | C19H36N2O3 |
分子量 | 340.501 |
别名 | |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,2-8°C |
溶解度 |
DMSO: 25 mg/mL(73.42 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |