产品说明书

CUDA

Print
Chemical Structure| 479413-68-8 同义名 : -
CAS号 : 479413-68-8
货号 : A1209356
分子式 : C19H36N2O3
纯度 : 97%
分子量 : 340.501
MDL号 : MFCD12912266
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(73.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CUDA is a potent inhibitor of sEH with an IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1].CUDA selectively enhances peri-PPARα activity and functions as a PPARα ligand, i.e., it competitively inhibits the binding of Wy-14643 to the PPARα ligand binding domain. At a concentration of 10 μM for 18 hours, CUDA increased PPARα activity in COS-7 cells by 6-fold and 3-fold, respectively[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.68mL

2.94mL

1.47mL

29.37mL

5.87mL

2.94mL
参考文献

[1]Morisseau C, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002 May 1;63(9):1599-608.

[2]Fang X, et al. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70.