CC-401 HCl | JNK Inhibitor | AmBeed-信号通路专用抑制剂

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CC-401 HCl {[allProObj[0].p_purity_real_show]}

货号：A101734 同义名： CC-401 Hydrochloride

CC-401 HCl是一种选择性且ATP竞争性的JNK抑制剂，Ki值范围为25-50 nM。

CC-401 HCl 化学结构
CAS号：1438391-30-0

CC-401 HCl 3D分子结构
CAS号：1438391-30-0

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CC-401 HCl 纯度/质量文件产品仅供科研

货号：A101734 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

JNK 亚型比较

产品名称	JNK ↓ ↑	JNK1 ↓ ↑	JNK2 ↓ ↑	JNK3 ↓ ↑	其他靶点	纯度
Mulberroside A	✔					99%+
Loureirin B	✔				Calcium Channel,Potassium Channel	99%+
Ginsenoside Re	✔				NF-κB	98%
(+)-(3R,8S)-Falcarindiol	✔				STAT,ERK	99%+
trans-Zeatin	✔				p38 MAPK,ERK	95+%
Urolithin B	✔				ERK,NF-κB	95%
Cucurbitacin IIb	✔				NF-κB	99%
Astragaloside IV	✔				Akt,mTOR,NF-κB	98%
NDMC101	✔					99%+
DB07268		++++ JNK1, IC50: 9 nM				99%+
SP600125	+ MKK4, IC50: 0.4 μM	+++ JNK1, IC50: 40 nM	+++ JNK2, IC50: 40 nM	+++ JNK3, IC50: 90 nM		98%
JNK-IN-7		++++ JNK1, IC50: 1.5 nM	++++ JNK2, IC50: 2 nM	++++ JNK3, IC50: 0.7 nM		99%
JNK-IN-8		++++ JNK1, IC50: 4.7 nM	+++ JNK2, IC50: 18.7 nM	++++ JNK3, IC50: 1 nM		99%+
3,3',5-Triiodo-L-thyronine		++ JNK1, Kd: 240 nM	++ JNK2, Kd: 290 nM	+++ JNK3, Kd: 66 nM		98%
IQ-1S free acid		+ JNK1, IC50: 390 nM	++ JNK2, IC50: 360 nM	+++ JNK3, IC50: 87 nM		99%
BI-78D3	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM		99%+
Bentamapimod		+++ JNK1, IC50: 80 nM	+++ JNK2, IC50: 90 nM	++ JNK3, IC50: 230 nM		98%
Resveratrol		+ JNK1, IC50: 50 μM				98%
Indirubin-3′-oxime		✔				99%+
SU3327	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM		99%+
JNK Inhibitor VIII		++++ JNK1, Ki: 2 nM JNK1, IC50: 45 nM	++++ JNK2, IC50: 160 nM JNK2, Ki: 4 nM	+++ JNK3, Ki: 52 nM		98%
Doramapimod			✔			99%+
RPI-1			✔			99%
TCS JNK 5a			++ JNK2, pIC50: 6.5	++ JNK3, pIC50: 6.7		98%
SP 600125, negative control			+ JNK2, IC50: 18 μM	+ JNK3, IC50: 24 μM		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

CC-401 HCl 生物活性

描述

The c-Jun N-terminal kinase (JNK) signaling plays an important role in tubular cell apoptosis. CC-401 is a potent, small-molecule JNK inhibitor with K_i values of 25-50nM for three forms of JNK. It inhibits JNK in cell-based assays at a concentration of 1-5μM. CC-401 dose-dependently inhibited sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cell line at doses of 0.25-4μM. The oral administration of rats underwent unilateral ureteral obstruction with CC-401 (100mg/kg, twice daily) for 7 days reduced interstitial volume, the accumulation of α-SMA+ myofibroblasts, and collagen IV deposition as compared to the vehicle-treated group. Rats treated with CC-401 also showed reduced mRNA expressions of TGF-β1, connective tissue growth factor, and collagen IV in the kidney compared with vehicle-treated animals^[3].

作用机制

CC-401 is a JNK inhibitor that competitively binds to the ATP binding site of JNK, inhibiting the phosphorylation of the N-terminal activation domain of c-Jun^[3].

CC-401 HCl 参考文献

[1]Vasilevskaya IA, Selvakumaran M, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.

[2]Uehara T, Bennett B, et al. JNK mediates hepatic ischemia reperfusion injury.J Hepatol. 2005 Jun;42(6):850-9.

[3]Ma FY, Flanc RS, Tesch GH, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007;18(2):472-484. doi:10.1681/ASN.2006060604

CC-401 HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.24mL

11.77mL

2.35mL

1.18mL

23.53mL

4.71mL

2.35mL

CC-401 HCl 技术信息

CAS号	1438391-30-0
分子式	C₂₂H₂₅ClN₆O
分子量	424.926

别名	CC-401 Hydrochloride
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 105 mg/mL(247.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 12 mg/mL(28.24 mM)，配合低频超声助溶

动物实验配方

CC-401 HCl {[allProObj[0].p_purity_real_show]}

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CC-401 HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

CC-401 HCl 质控信息

CC-401 HCl 生物活性

CC-401 HCl 参考文献

CC-401 HCl 实验方案

CC-401 HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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CC-401 HCl 纯度/质量文件产品仅供科研