C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
C-DIM12 is characterized as a potent and orally efficacious antagonist of Nurr1, known for suppressing tumor proliferation and autophagy while promoting cell apoptosis. It exhibits both anti-inflammatory and neuroprotective properties, making it suitable for research in cancer and neurological disorders. Through its actions, C-DIM12 mitigates tumor growth and cellular self-digestion processes and encourages cell programmed death, contributing to its utility in scientific investigations related to oncology and neurology1].[2].[3].
体内研究
When given intraperitoneally at 25 mg/kg for 14 days, it adjusts glial responsiveness in mice models of MPTP-induced Parkinson's disease[2].
Furthermore, with a dosage of 50-100 mg/kg administered intraperitoneally thrice, it lessens brain inflammation and aids in functional recuperation post-intracerebral hemorrhage in mice.
At 30 mg/kg for 30 days via the same route, C-DIM12 hampers the growth of tumors and autophagy, while inducing apoptosis in NURR1-KO cells within orthotopic xenografts[1].
体外研究
Administering C-DIM12 at a concentration of 15 μM for a duration of 3-5 days enhances both proliferation and survival rates of MiaPaCa2 cells by impeding autophagic processes[1].
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