货号:A179040 同义名: 4-Chlorophenyl-3,3'-diindolylmethane
C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
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产品名称 | ALK1 ↓ ↑ | ALK2 ↓ ↑ | ALK3 ↓ ↑ | ALK4 ↓ ↑ | ALK6 ↓ ↑ | Smad3 ↓ ↑ | TGF-β ↓ ↑ | TGFβRI/ALK5 ↓ ↑ | TGFβRII ↓ ↑ | 其他靶点 | 纯度 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LDN193189 |
++++
ALK1, IC50: 0.8 nM |
++++
ALK2, IC50: 0.8 nM |
+++
ALK3, IC50: 5.3 nM |
+++
ALK6, IC50: 16.7 nM |
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LDN-212854 |
++++
ALK1, IC50: 2.4 nM |
++++
ALK2, IC50: 1.3 nM |
+
ALK3, IC50: 85.8 nM |
+
ALK4, IC50: 2133 nM |
+
ALK5, IC50: 9276 nM |
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ML347 |
++
ALK1, IC50: 46 nM |
++
ALK2, IC50: 32 nM |
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K02288 |
++++
ALK1, IC50: 1.8 nM |
++++
ALK2, IC50: 1.1 nM |
++
ALK3, IC50: 34.4 nM |
+++
ALK6, IC50: 6.4 nM |
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LDN-193189 dihydrochloride |
++++
ALK1, IC50: 0.8 nM |
++++
ALK2, IC50: 0.8 nM |
+++
ALK3, IC50: 5.3 nM |
+++
ALK6, IC50: 16.7 nM |
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LDN-214117 |
++
ALK2, IC50: 24 nM |
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DMH-1 |
+
ALK2, IC50: 107.9 nM |
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SB-505124 |
+
ALK4, IC50: 129 nM |
++
ALK5, IC50: 47 nM |
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Vactosertib |
+++
ALK4, IC50: 13 nM |
+++
ALK5, IC50: 11 nM |
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Alantolactone | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SIS3 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Pirfenidone | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Hesperetin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
RepSox |
++++
TGFβR1(ALK5), IC50: 4 nM |
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GW788388 |
+++
ALK5, IC50: 18 nM |
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LY364947 |
++
TGFβRI, IC50: 59 nM |
+
TGFβRII, IC50: 0.4 μM |
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SD-208 |
++
TGF-βRI (ALK5), IC50: 48 nM |
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SB-525334 |
+++
TGFβR1(ALK5), IC50: 14.3 nM |
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LY2109761 |
++
TβRI, Ki: 38 nM |
+
TβRII, Ki: 300 nM |
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Galunisertib |
++
TβRI, IC50: 56 nM |
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SB 431542 |
+
ALK5, IC50: 94 nM |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | Autophagy ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SBI-0206965 |
+++
ULK2, IC50: 711 nM ULK1, IC50: 108 nM |
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Hydroxychloroquine sulfate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Valproic acid sodium | ✔ | HDAC | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PFK-015 |
++
PFKFB3, IC50: 207 nM |
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MRT68921 hydrochloride |
++++
ULK2, IC50: 1.1 nM ULK1, IC50: 2.9 nM |
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ROC-325 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Autophinib |
+++
Autophagy, IC50: 40 nM |
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Lys05 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | C-DIM12 is characterized as a potent and orally efficacious antagonist of Nurr1, known for suppressing tumor proliferation and autophagy while promoting cell apoptosis. It exhibits both anti-inflammatory and neuroprotective properties, making it suitable for research in cancer and neurological disorders. Through its actions, C-DIM12 mitigates tumor growth and cellular self-digestion processes and encourages cell programmed death, contributing to its utility in scientific investigations related to oncology and neurology1].[2].[3]. |
体内研究 | When given intraperitoneally at 25 mg/kg for 14 days, it adjusts glial responsiveness in mice models of MPTP-induced Parkinson's disease[2]. Furthermore, with a dosage of 50-100 mg/kg administered intraperitoneally thrice, it lessens brain inflammation and aids in functional recuperation post-intracerebral hemorrhage in mice. At 30 mg/kg for 30 days via the same route, C-DIM12 hampers the growth of tumors and autophagy, while inducing apoptosis in NURR1-KO cells within orthotopic xenografts[1]. |
体外研究 | Administering C-DIM12 at a concentration of 15 μM for a duration of 3-5 days enhances both proliferation and survival rates of MiaPaCa2 cells by impeding autophagic processes[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.80mL 0.56mL 0.28mL |
14.01mL 2.80mL 1.40mL |
28.02mL 5.60mL 2.80mL |
CAS号 | 178946-89-9 |
分子式 | C23H17ClN2 |
分子量 | 356.848 |
别名 | 4-Chlorophenyl-3,3'-diindolylmethane |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(294.24 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |