货号:A714436
同义名:
马兜铃酸
/ Aristolochic acid I;TR 1736
Aristolochic acid A是一种从马兜铃科植物(Aristolochia debilis Sieb. et Zucc.)中提取的天然产物,强烈引起卵巢成熟过程中通过抑制Akt磷酸化介导的凋亡抑制的毒性损伤。
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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
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技术支持
免费溶解
产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PDTC ammonium | ✔ | 98% | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
99%+ | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | 98% | |||||||||||||||||
Sodium Salicylate | ✔ | 95% | |||||||||||||||||
Parthenolide | ✔ | p53 | 97% HPLC | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
98% | |||||||||||||||||
Phenethyl caffeate | ✔ | 98% | |||||||||||||||||
Andrographolide | ✔ | 98+% | |||||||||||||||||
Curcumin | ✔ | HDAC,Nrf2 | 98% | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
99%+ | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | 99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Aristolochic Acid A (Aristolochic acid I), is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis. Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376). Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[3]. AA (Aristolochic Acid A) has been found to damage broilers' kidneys by breaking the redox balance to form oxidative stress, along with promoting apoptosis of renal cells[4]. Additionally, AAI promoted apoptosis in SSCs, which was accompanied by upregulation of caspase 3, P53 and BAX expression and downregulation of Bcl-2 expression, and suppressed autophagy, which was accompanied by upregulation of P62 expression and downregulation of ATG5 and LC3B expression, in a concentration-dependent manner. AAI (Aristolochic acid I) impaired spermatogenesis in rats, as identified by degeneration of the seminiferous epithelium, and increased apoptosis of testicular cells[5]. The mechanism of AA-I-induced hepatotoxicity was associated with oxidative-stress-mediated apoptosis and mitochondrial damage[6]. |
Animal study | 肾毒性[5] 动物: BALB/c 小鼠,~20 g。 给药:10 mg/kg/天,腹腔注射,3-5天。 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03066921 | End Stage Renal Disease | Not Applicable | Completed | - | Taiwan ... 展开 >> Tungs' Taichung MetroHarbour Hospital Taichung, Taiwan 收起 << |
NCT01503645 | - | Unknown | - | Taiwan ... 展开 >> Far Estern Memorial Hospital Not yet recruiting Pan-Chiao, Taipei, Taiwan, 22060 National Taiwan University Hospital Recruiting Taipei, Taiwan, 10051 Contact: Kwan-Dun Wu, MD, PhD +886-2-23123456 ext 5014 kdw@ntumc.org Principal Investigator: Fe-Lin L Wu, Ph.D. 收起 << | |
NCT00867633 | - | Unknown | March 2012 | Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yeong-Shiau Pu, Ph.D. 886-2-23123456 ext 65249 yspu@ntu.edu.tw 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.93mL 0.59mL 0.29mL |
14.65mL 2.93mL 1.47mL |
29.30mL 5.86mL 2.93mL |
CAS号 | 313-67-7 |
分子式 | C17H11NO7 |
分子量 | 341.272 |
别名 | 马兜铃酸 ;Aristolochic acid I;TR 1736;AristA;Birthwort;Tardolyt;NSC 50413;NSC 11926;Aristolochic Acid;Aristolochine;Aristolochin |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere,2-8°C |
溶解方案 |
DMSO: 16 mg/mL(46.88 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |