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马兜铃酸A /Aristolochic acid A {[allProObj[0].p_purity_real_show]}

货号:A714436 同义名: 马兜铃酸 / Aristolochic acid I;TR 1736

Aristolochic acid A是一种从马兜铃科植物(Aristolochia debilis Sieb. et Zucc.)中提取的天然产物,强烈引起卵巢成熟过程中通过抑制Akt磷酸化介导的凋亡抑制的毒性损伤。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Aristolochic acid A 化学结构 CAS号:313-67-7
Aristolochic acid A 化学结构
CAS号:313-67-7
Aristolochic acid A 3D分子结构
CAS号:313-67-7
Aristolochic acid A 化学结构 CAS号:313-67-7
Aristolochic acid A 3D分子结构 CAS号:313-67-7
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Aristolochic acid A 纯度/质量文件 产品仅供科研

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产品名称 NF-κB 其他靶点 纯度
PDTC ammonium 98%
QNZ ++++

NF-κB, IC50: 11 nM

99%+
Sodium 4-Aminosalicylate Dihydrate 98%
Sodium Salicylate 95%
Parthenolide p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

98%
Phenethyl caffeate 98%
Andrographolide 98+%
Curcumin HDAC,Nrf2 98%
SC75741 +++

NF-κB, EC50: 200 nM

99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Aristolochic acid A 生物活性

描述 Aristolochic Acid A (Aristolochic acid I), is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis. Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376). Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[3]. AA (Aristolochic Acid A) has been found to damage broilers' kidneys by breaking the redox balance to form oxidative stress, along with promoting apoptosis of renal cells[4]. Additionally, AAI promoted apoptosis in SSCs, which was accompanied by upregulation of caspase 3, P53 and BAX expression and downregulation of Bcl-2 expression, and suppressed autophagy, which was accompanied by upregulation of P62 expression and downregulation of ATG5 and LC3B expression, in a concentration-dependent manner. AAI (Aristolochic acid I) impaired spermatogenesis in rats, as identified by degeneration of the seminiferous epithelium, and increased apoptosis of testicular cells[5]. The mechanism of AA-I-induced hepatotoxicity was associated with oxidative-stress-mediated apoptosis and mitochondrial damage[6].

Aristolochic acid A 动物研究

Animal study 肾毒性[5]
动物: BALB/c 小鼠,~20 g。
给药:10 mg/kg/天,腹腔注射,3-5天。

Aristolochic acid A 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03066921 End Stage Renal Disease Not Applicable Completed - Taiwan ... 展开 >> Tungs' Taichung MetroHarbour Hospital Taichung, Taiwan 收起 <<
NCT01503645 - Unknown - Taiwan ... 展开 >> Far Estern Memorial Hospital Not yet recruiting Pan-Chiao, Taipei, Taiwan, 22060 National Taiwan University Hospital Recruiting Taipei, Taiwan, 10051 Contact: Kwan-Dun Wu, MD, PhD    +886-2-23123456 ext 5014    kdw@ntumc.org    Principal Investigator: Fe-Lin L Wu, Ph.D. 收起 <<
NCT00867633 - Unknown March 2012 Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yeong-Shiau Pu, Ph.D.    886-2-23123456 ext 65249    yspu@ntu.edu.tw 收起 <<

Aristolochic acid A 参考文献

[1]Kwak DH, Park JH, et al. Aristolochic Acid I induces ovarian toxicity by inhibition of akt phosphorylation. Chem Res Toxicol. 2014 Dec 15;27(12):2128-35.

[2]Pan JH, Yan GJ, Song J. [The determination of aristolochic acid A in different processed Aristolochia manshuriensis and the test of influence about renal function in rats] . Zhong Yao Cai. 2010 Aug;33(8):1228-33. Chinese.

[3]Huang YT, Wu TS, Lu CC, Yu FY, Liu BH. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137

[4]Xu D, Ran C, Yin L, Lin J, Fu H, Peng X, Zhao X, Shu G. Acute and Subchronic Toxicity Studies of Aristolochic Acid A in Tianfu Broilers. Animals (Basel). 2021 May 27;11(6):1556

[5]Liu Y, He X, Wang Y, Zhou H, Zhang Y, Ma J, Wang Z, Yang F, Lu H, Yang Y, Deng Z, Qi X, Gong L, Ren J. Aristolochic acid I induces impairment in spermatogonial stem cell in rodents. Toxicol Res (Camb). 2021 Apr 26;10(3):436-445

[6]Xu D, Yin L, Lin J, Fu H, Peng X, Chang L, Zheng Y, Zhao X, Shu G. Aristolochic Acid I-Induced Hepatotoxicity in Tianfu Broilers Is Associated with Oxidative-Stress-Mediated Apoptosis and Mitochondrial Damage. Animals (Basel). 2021 Dec 2;11(12):3437

[7]Zeng Y, Li S, Wu J, Chen W, Sun H, Peng W, Yu X, Yang X. Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model. Apoptosis. 2014 Aug;19(8):1215-24.

Aristolochic acid A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.65mL

2.93mL

1.47mL

29.30mL

5.86mL

2.93mL

Aristolochic acid A 技术信息

CAS号313-67-7
分子式C17H11NO7
分子量 341.272
别名 马兜铃酸 ;Aristolochic acid I;TR 1736;AristA;Birthwort;Tardolyt;NSC 50413;NSC 11926;Aristolochic Acid;Aristolochine;Aristolochin
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C

溶解方案

DMSO: 16 mg/mL(46.88 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
动物实验配方
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