货号:A714436 同义名: 马兜铃酸 / Aristolochic acid I;TR 1736
Aristolochic acid A, a natural product isolated and purified from the herb of Aristolochia debilis Sieb. et Zucc. and a potent rephrotoxin, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis.
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Limited Quantity | USD 15-60 |
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产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pyrrolidinedithiocarbamate ammonium | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sodium Salicylate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Parthenolide | ✔ | p53 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Phenethyl caffeate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Andrographolide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Curcumin | ✔ | HDAC,Nrf2 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Aristolochic Acid A (Aristolochic acid I), is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis. Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376). Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[3]. AA (Aristolochic Acid A) has been found to damage broilers' kidneys by breaking the redox balance to form oxidative stress, along with promoting apoptosis of renal cells[4]. Additionally, AAI promoted apoptosis in SSCs, which was accompanied by upregulation of caspase 3, P53 and BAX expression and downregulation of Bcl-2 expression, and suppressed autophagy, which was accompanied by upregulation of P62 expression and downregulation of ATG5 and LC3B expression, in a concentration-dependent manner. AAI (Aristolochic acid I) impaired spermatogenesis in rats, as identified by degeneration of the seminiferous epithelium, and increased apoptosis of testicular cells[5]. The mechanism of AA-I-induced hepatotoxicity was associated with oxidative-stress-mediated apoptosis and mitochondrial damage[6]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03066921 | End Stage Renal Disease | Not Applicable | Completed | - | Taiwan ... 展开 >> Tungs' Taichung MetroHarbour Hospital Taichung, Taiwan 收起 << |
NCT01503645 | - | Unknown | - | Taiwan ... 展开 >> Far Estern Memorial Hospital Not yet recruiting Pan-Chiao, Taipei, Taiwan, 22060 National Taiwan University Hospital Recruiting Taipei, Taiwan, 10051 Contact: Kwan-Dun Wu, MD, PhD +886-2-23123456 ext 5014 kdw@ntumc.org Principal Investigator: Fe-Lin L Wu, Ph.D. 收起 << | |
NCT00867633 | - | Unknown | March 2012 | Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yeong-Shiau Pu, Ph.D. 886-2-23123456 ext 65249 yspu@ntu.edu.tw 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.93mL 0.59mL 0.29mL |
14.65mL 2.93mL 1.47mL |
29.30mL 5.86mL 2.93mL |
CAS号 | 313-67-7 |
分子式 | C17H11NO7 |
分子量 | 341.272 |
别名 | 马兜铃酸 ;Aristolochic acid I;TR 1736;AristA;Birthwort;Tardolyt;NSC 50413;NSC 11926;Aristolochic Acid;Aristolochine;Aristolochin |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 16 mg/mL(46.88 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |