E3330 (APX-3330) 是一种直接的、口服活性的、选择性的 Ape-1（无嘌呤/无嘧啶核酸内切酶 1）/Ref-1（氧化还原因子 1）抑制剂。E3330 抑制 NF-κB、AP-1 和 HIF-1α 在胰腺癌组织中的活性，具有抗癌活性。

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function.

Aristolochic acid A, a natural product isolated and purified from the herb of Aristolochia debilis Sieb. et Zucc. and a potent rephrotoxin, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis.

Fargesin is a lignan from Magnolia fargesii, an oriental medicine used in the treatment of nasal congestion and sinusitis.

SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor.

Fargesin, a natural product isolated and purified from Flos Magnoliae, exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling.

Methyllinderone is a natural product isolated and purified from the roots of Lindera aggregata(Sims) Kosterm, showing moderate to weak antifungal activities against various pathogenic fungi, and selectively inhibits the growth of H-ras-transformed rat-2 cell lines with a GI50 value of 0.3 mM.

Ganoderic acid, a triterpene found in Ganoderma mushrooms, is reported to exhibit anti-tumor activity mediated through its inhibitory effect on NFKB and AP-1 as well as antimetastasis and anti-HIV activities.

CFM 4, the CARP-1 mimetic, can interfere with CARP-1 binding to APC-2, enhance CARP-1 expression and induces G2/M cell cycle arrest and apoptosis and suppresses cell growth in cancer cells.

PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 μM without affecting NF-kappaB transcription (up to 200 μM) or thioredoxin (up to 200 μM).

Torilin, a natural product isolated and purified from the fruits of Torilis japonica with anti-inflammatory, antimicrobial, anti-angiogenic, antitumor and hepatoprotective properties.