GDC-0152 is a potent inhibitor of IAPs and binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K (i) values of 28, 14, 17, and 43 nM, respectively.

LCL161是一种IAP抑制剂，在HEK293细胞中抑制XIAP，在MDA-MB-231细胞中抑制cIAP1，IC50值分别为35 nM和0.4 nM。

SM-164是一种细胞可渗透的Smac模拟物化合物，以1.39 nM的IC50值结合含有BIR2和BIR3域的XIAP蛋白，作为一种极其有效的XIAP拮抗剂。

Birinapant（TL32711）是一种双价Smac模拟物和有效的XIAP和cIAP1拮抗剂，Kd值分别为45 nM和小于1 nM。Birinapant诱导cIAP1和cIAP2在细胞中的自泛素化和蛋白酶体降解，导致RIPK1复合物的形成、caspase-8的激活和肿瘤细胞死亡。它靶向与TRAF2相关的cIAP，并消除TNF诱导的NF-κB激活。

AZD5582 is a class of dimeric Smac mimetics as potent IAP antagonist and binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively).

An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities.

Xevinapant (AT-406) 是一种有效的口服生物可利用的 Smac 模拟物，作为 IAPs 的拮抗剂，能够抑制 XIAP、cIAP1 和 cIAP2 蛋白，其 Ki 值分别为 66.4、1.9 和 5.1 nM。

BV6作为一种拮抗剂，靶向cIAP1和XIAP，它们是抑制凋亡蛋白（IAP）家族的成员。

Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.

FL118是一种口服有效的Survivin抑制剂，通过结合DDX5（p68）蛋白并诱导其去磷酸化与降解，展示了在癌症治疗中的潜力，主要用于肿瘤细胞增殖和存活机制的研究。

Isolinderalactone通过抑制内皮细胞 VEGFR2 活化，抑制人胶质母细胞瘤的生长和血管生成，同时抑制 Bcl-2、survivin 和 XIAP 的表达，并增加 cleaved caspase-3 水平。

E3 ligase Ligand 9 is a Bestatin-based E3 ligase ligand.

Polygalacin D, a natural product isolated and purified from the roots of Polygala tenuifolia Willd, can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2), exhibit significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i.