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E3 ligase Ligand 9
E3 ligase Ligand 9
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货号：A472273
E3 ligase Ligand 9 is a Bestatin-based E3 ligase ligand.
E3 ligase Ligand 9 化学结构
E3 ligase Ligand 9 3D分子结构
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E3 ligase Ligand 9 纯度/质量文件 产品仅供科研
货号：A472273
标准纯度：
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产品说明书
全球学术期刊中引用的产品
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• PloS One , 2024, 19(11): e0308060. Ambeed. 更多 >
E3 ligase Ligand 9 质控信息
LCL161
✔
99%+
AZD5582
+++
cIAP2, IC50: 21 nM
cIAP1, IC50: 15 nM
+++
99%+
Birinapant
++++
++
98+%
GDC-0152
+++
cIAP2-BIR3, Ki: 43 nM
cIAP1-BIR3, Ki: 17 nM
++
XIAP-BIR2, Ki: 112 nM
XIAP-BIR3, Ki: 28 nM
99%+
Xevinapant
++++
cIAP2-BIR3, Ki: 5.1 nM
cIAP1-BIR3, Ki: 1.9 nM
+
99%+
Embelin
+
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
E3 ligase Ligand 9 生物活性
描述
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1] [2] [3]
E3 ligase Ligand 9 参考文献
[1] Bricelj A, Steinebach C, Kuchta R, Gütschow M, Sosič I. E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points. Front Chem. 2021 Jul 5;9:707317
[2] Shu L, Zhang H, Boyce BF, Xing L. Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration. J Bone Miner Res. 2013 Sep;28(9):1925-35
[3] Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL, Liu H. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics. 2020 Mar 4;10(9):4150-4167
E3 ligase Ligand 9 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.45mL
0.49mL
0.24mL
12.24mL
2.45mL
1.22mL
24.48mL
4.90mL
2.45mL
E3 ligase Ligand 9 技术信息
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