Embelin | 恩贝酸/恩贝灵 | Emberine | XIAP Inhibitor

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恩贝酸 /Embelin 99%+

货号：A116360 同义名： 恩贝酸/恩贝灵 / Emberine;NSC 91874

Embelin, a quinone isolated from the Japanese Ardisia herb, is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.

Embelin 化学结构
CAS号：550-24-3

Embelin 3D分子结构
CAS号：550-24-3

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Embelin 纯度/质量文件产品仅供科研

货号：A116360 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

IAP 亚型比较

产品名称	cIAP ↓ ↑	XIAP ↓ ↑	纯度
LCL161	✔		99%+
AZD5582	+++ cIAP1, IC50: 15 nM cIAP2, IC50: 21 nM	+++ XIAP, IC50: 15 nM	99%+
Birinapant	++++ cIAP1, Kd: <1 nM	++ XIAP, Kd: 45 nM	98+%
GDC-0152	+++ cIAP2-BIR3, Ki: 43 nM cIAP1-BIR3, Ki: 17 nM	++ XIAP-BIR3, Ki: 28 nM XIAP-BIR2, Ki: 112 nM	99%+
Xevinapant	++++ cIAP2-BIR3, Ki: 5.1 nM cIAP1-BIR3, Ki: 1.9 nM	+ XIAP-BIR3, Ki: 66.4 nM	99%+
Embelin		+ XIAP, IC50: 4.1 μM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Embelin 生物活性

靶点	XIAP XIAP, IC50:4.1 μM
描述	Embelin is a potent XIAP inhibitor with IC50 value of 4.1μM (measured by FP-based biochemical binding assay) ^[1]. Pretreatment with embelin 12h prior to TNFα at concentration ranging in 10-50μM can dose-dependently inhibit TNFα-induced NF-κB activation by inhibiting IκB degradation, as well as inhibted TNFα-induced p65 nuclear translocation due to inhibition of p65 phosphorylation in KBM-5 cells. with no affect on protein level of IAP1, IAP2 and XIAP. Exposure to 50μM embelin for 6-24h could reduce the antiapoptotic proteins survivin, IAP1/2, and suppress Bcl-xL, cFLIP, and TRAF1, suppress the cell proliferation gene expression, including COX-2, cyclin D1 and c-Myc, as well as gene products involved in tumor metastasis, including VEGF, MMP-9 and ICAM-1, which were all TNF-induced NF-κB-dependent^[2]. The induction of autophagic and apoptotic cell death by embelin can also be observed in human oral squamous cell carcinoma Ca9-22 cell line^[3]. Neonatal injections of 20mg/kg embelin, s.c., could exacerbate hypoxia-ischemia-induced persistent behavioral deficits in female rats on postnatal day 7, but not in male rats^[4].
作用机制	Embelin bind to the XIAP-BIR3 domain where caspase-9 and Smac proteins bind. ^[1]

Embelin 动物研究

Dose

Rat: min = 15 mg/kg, max = 120 mg/kg^[5] (p.o.); 5 mg/kg^[5] (i.v.); 0.3 mg/kg - 1.2 mg/kg^[6] (i.p.)

Administration

p.o., i.v., i.p.

Pharmacokinetics

Animal	Rats^[5]
Dose	5 mg/kg (i.v.) 15 mg/kg (p.o.)
Administration	i.v. p.o.
AUC_0→24h	2.17 ± 0.49 μg/ml·h (i.v.) 1.97 ± 0.78 μg/ml·h (p.o.)
MRT_0→24	1.28 ± 0.11 h (i.v.) 1.49 ± 0.49 h (p.o.)
T_1/2	1.52 ± 0.83 h (i.v.) 1.01 ± 0.58 h (p.o.)
T_max	0.03 ± 0.00 h (i.v.) 0.71 ± 0.19 h (p.o.)
C_max	3.91 ± 1.34 μg/ml (i.v.) 1.05 ± 0.21 μg/ml (p.o.)
AUC_0→∞	3.21 ± 0.62 μg/ml·h (i.v.) 2.92 ± 0.69 μg/ml·h (p.o.)
MRT_0→∞	3.43 ± 0.41 h (i.v.) 3.21 ± 1.15 h (p.o.)

Embelin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02785172	Psoriasis	Phase 2	Completed	-	United States, California ... 展开 >> Valeant Site 12 Fullerton, California, United States, 92831 Valeant Site 04 La Mesa, California, United States, 91941 Valeant Site 03 San Diego, California, United States, 92093 Valeant Site 09 San Diego, California, United States, 92093 United States, Florida Valeant Site 05 Lauderdale Lakes, Florida, United States, 33313 Valeant Site 02 Miami, Florida, United States, 33111 United States, Minnesota Valeant Site 07 Fridley, Minnesota, United States, 55421 United States, North Carolina Valeant Site 08 Chapel Hill, North Carolina, United States, 27514 United States, Ohio Valeant Site 06 Columbus, Ohio, United States, 43085 United States, South Carolina Valeant Site 13 Mount Pleasant, South Carolina, United States, 29464 United States, Texas Valeant Site 11 Katy, Texas, United States, 77449 Valeant Site 10 San Antonio, Texas, United States, 78201 Valeant Site 01 Sugar Land, Texas, United States, 77479 United States, Utah Valeant Site 14 Salt Lake City, Utah, United States, 84103 收起 <<
NCT03058744	Psoriasis	Phase 1	Completed	-	United States, California ... 展开 >> Valeant Site 12 Anaheim, California, United States, 92801 Valeant Site 05 Encino, California, United States, 91436 Valeant Site 01 San Diego, California, United States, 92093 Valeant Site 07 Santa Rosa, California, United States, 95401 United States, Florida Valeant Site 10 Orange Park, Florida, United States, 32065 Valeant Site 09 Sanford, Florida, United States, 32771 United States, Georgia Valeant Site 08 Atlanta, Georgia, United States, 30301 United States, Indiana Valeant Site 04 Plainfield, Indiana, United States, 46168 United States, New York Valeant Site 06 New York, New York, United States, 10001 United States, Pennsylvania Valeant Site 11 Philadelphia, Pennsylvania, United States, 19019 United States, Texas Valeant Site 03 Austin, Texas, United States, 73301 Valeant Site 02 Katy, Texas, United States, 77449 收起 <<
NCT01567215	Fetus or Newborn Affected by C... 展开 >>ondition of Umbilical Cord 收起 <<	Phase 2	Completed	-	Denmark ... 展开 >> Hvidovre Hospital Kettegård Alle 31, Hvidovre, Denmark, 2650 Hvidovre University Hospital Hvidovre, Kettegård alle 30, Denmark, 2650 收起 <<

Embelin 参考文献

[1]Nikolovska-Coleska Z, Xu L, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004 May 6;47(10):2430-40.

[2]Ahn KS, Sethi G, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007 Jan;71(1):209-19. Epub 2006 Oct 6.

[3]Lee YJ, Park BS, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017 Nov;32(11):2371-2378.

[4]Hill CA, Alexander ML, et al. Inhibition of X-linked inhibitor of apoptosis with embelin differentially affects male versus female behavioral outcome following neonatal hypoxia-ischemia in rats. Dev Neurosci. 2011;33(6):494-504.

[5]Li Z, Chen SJ, et al. Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats. Evid Based Complement Alternat Med. 2019 Mar 20;2019:9682495.

[6]Bhuvanendran S, Kumari Y, et al. Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer's Disease-Like Condition in a Rat Model. Front Pharmacol. 2018 Jun 25;9:665.

Embelin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.98mL

3.40mL

1.70mL

33.97mL

6.79mL

3.40mL

Embelin 技术信息

CAS号	550-24-3
分子式	C₁₇H₂₆O₄
分子量	294.386

别名	恩贝酸/恩贝灵 ;Emberine;NSC 91874;Embelic acid
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(169.85 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02785172	Psoriasis	Phase 2	Completed	-	United States, California ... 展开 >> Valeant Site 12 Fullerton, California, United States, 92831 Valeant Site 04 La Mesa, California, United States, 91941 Valeant Site 03 San Diego, California, United States, 92093 Valeant Site 09 San Diego, California, United States, 92093 United States, Florida Valeant Site 05 Lauderdale Lakes, Florida, United States, 33313 Valeant Site 02 Miami, Florida, United States, 33111 United States, Minnesota Valeant Site 07 Fridley, Minnesota, United States, 55421 United States, North Carolina Valeant Site 08 Chapel Hill, North Carolina, United States, 27514 United States, Ohio Valeant Site 06 Columbus, Ohio, United States, 43085 United States, South Carolina Valeant Site 13 Mount Pleasant, South Carolina, United States, 29464 United States, Texas Valeant Site 11 Katy, Texas, United States, 77449 Valeant Site 10 San Antonio, Texas, United States, 78201 Valeant Site 01 Sugar Land, Texas, United States, 77479 United States, Utah Valeant Site 14 Salt Lake City, Utah, United States, 84103 收起 <<
NCT03058744	Psoriasis	Phase 1	Completed	-	United States, California ... 展开 >> Valeant Site 12 Anaheim, California, United States, 92801 Valeant Site 05 Encino, California, United States, 91436 Valeant Site 01 San Diego, California, United States, 92093 Valeant Site 07 Santa Rosa, California, United States, 95401 United States, Florida Valeant Site 10 Orange Park, Florida, United States, 32065 Valeant Site 09 Sanford, Florida, United States, 32771 United States, Georgia Valeant Site 08 Atlanta, Georgia, United States, 30301 United States, Indiana Valeant Site 04 Plainfield, Indiana, United States, 46168 United States, New York Valeant Site 06 New York, New York, United States, 10001 United States, Pennsylvania Valeant Site 11 Philadelphia, Pennsylvania, United States, 19019 United States, Texas Valeant Site 03 Austin, Texas, United States, 73301 Valeant Site 02 Katy, Texas, United States, 77449 收起 <<
NCT01567215	Fetus or Newborn Affected by C... 展开 >>ondition of Umbilical Cord 收起 <<	Phase 2	Completed	-	Denmark ... 展开 >> Hvidovre Hospital Kettegård Alle 31, Hvidovre, Denmark, 2650 Hvidovre University Hospital Hvidovre, Kettegård alle 30, Denmark, 2650 收起 <<
NCT00544687	Healthy	Phase 1	Completed	-	Germany ... 展开 >> bioskin GmbH Hamburg, Germany 收起 <<
NCT00865605	Healthy	Phase 1	Completed	-	United States, California ... 展开 >> DermTech International San Diego, California, United States, 92128 收起 <<
NCT00865267	Healthy	Phase 1	Completed	-	United States, California ... 展开 >> DermTech International San Diego, California, United States, 92128 收起 <<
NCT00990561	-		Completed	-	-
NCT00990561	Stable Plaque Psoriasis	Phase 4	Completed	-	United States, California ... 展开 >> UCSF Psoriasis and Skin Treatment Center San Francisco, California, United States, 94118 收起 <<
NCT00803166	-		Completed	-	-
NCT01166646	Plaque Psoriasis	Phase 2	Completed	-	United States, California ... 展开 >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Michigan Michigan Center for Skin Care Research (dba Skin Care Research) Clinton Township, Michigan, United States, 48038 Somerset Skin Centre Troy, Michigan, United States, 48084 United States, North Carolina Dermatology, Laser & Vein Specialists of the Carolinas PLLC Charlotte, North Carolina, United States, 28207 United States, Texas DermResearch Inc. Austin, Texas, United States, 78759 收起 <<
NCT01111123	-		Completed	-	-
NCT00802958	-		Completed	-	-
NCT01610596	Psoriasis Pla... 展开 >>que Psoriasis 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Minnesota Minnesota Clinical Study Center Fridley, Minnesota, United States, 55432 United States, Texas DermResearch, Inc. Austin, Texas, United States, 78759 收起 <<
NCT01567995	Eczema	Phase 3	Completed	-	China, Jiangsu ... 展开 >> GSK Investigational Site Nanjing, Jiangsu, China, 210029 GSK Investigational Site Nanjing, Jiangsu, China, 210042 China GSK Investigational Site Beijing, China, 100034 GSK Investigational Site Beijing, China, 100044 GSK Investigational Site Beijing, China, 100730 GSK Investigational Site Shanghai, China, 200040 GSK Investigational Site Tianjin, China, 300052 收起 <<
NCT01111123	Plaque Psoriasis	Phase 4	Completed	-	United States, New York ... 展开 >> Icahn School of Medicine at Mount Sinai, Department of Dermatology New York, New York, United States, 10029 收起 <<
NCT03212963	Plaque Psoriasis	Phase 4	Recruiting	December 2018	United States, Florida ... 展开 >> Olympian Clinical Research Recruiting Clearwater, Florida, United States, 33756 Contact: Matthew Brent Zook, MD, PhD 813-849-5566 Contact: Dustin SIegert 813-849-5566 dsiegert@olympianresearch.com Wisdom Clinical Research Institute, Corp. Recruiting Coral Gables, Florida, United States, 33134 Contact: Maria Carballosa, MD 305-443-3480 Contact: Dalila Diaz 305-443-3480 ddiaz@drmaritzafuentes.com ASCLEPES Research Center Recruiting Spring Hill, Florida, United States, 34609 Contact: Imad Jandali, MD kleonard@asclepes.com Contact: Katie Leonard 352-364-9427 kleonard@asclepes.com 收起 <<
NCT03245385	Atopic Dermatitis	Phase 2	Terminated(Sponsors decision)	-	United States, California ... 展开 >> Providence Clinical Research North Hollywood, California, United States, 91606 Havana Research Institute Pasadena, California, United States, 91105 United States, Florida Vital Pharma Research Hialeah, Florida, United States, 33016 Solutions Through Advanced Research Jacksonville, Florida, United States, 32256 Integrity Research Center Miami, Florida, United States, 33015 Millennium Clinical Research, INC Miami, Florida, United States, 33125 Regenerate Clinical Trials, LLC Miami, Florida, United States, 33155 Life Medical Center and Research, INC Miami, Florida, United States, 33166 Vista Health Research Miami, Florida, United States, 33176 United States, Michigan Elias Research Troy, Michigan, United States, 48085 United States, Montana Montana Medical Research/Elias Research Assoc. Missoula, Montana, United States, 49808 United States, Pennsylvania L&C Professional Medical Research Institute Hazleton, Pennsylvania, United States, 18201 United States, Texas Sun Research Institute San Antonio, Texas, United States, 78215 收起 <<
NCT03298581	Plaque Psoriasis	Phase 2	Withdrawn(Sponsor decision)	August 31, 2018	-
NCT01166646	-		Completed	-	-
NCT02123966	Chronic Graft-versus-Host-Dise... 展开 >>ase Oral Mucosal Disease Due to Graft-versus-host Disease 收起 <<	Phase 2	Terminated(Due to slow accrual... 展开 >>, study team has decided to end the study early.) 收起 <<	-	United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<
NCT02785185	Psoriasis	Phase 2	Completed	-	United States, Arkansas ... 展开 >> Valeant Site 05 Rogers, Arkansas, United States, 75758 United States, California Valeant Site 10 Beverly Hills, California, United States, 90210 Valeant Site 09 Carlsbad, California, United States, 92008 Valeant Site 13 Los Angeles, California, United States, 90045 Valeant Site 12 Santa Monica, California, United States, 90404 United States, Florida Valeant Site 07 Coral Gables, Florida, United States, 33134 Valeant Site 11 North Miami Beach, Florida, United States, 33162 Valeant Site 03 Sanford, Florida, United States, 32771 United States, Indiana Valeant Site 08 Albany, Indiana, United States, 47150 United States, Kentucky Valeant Site 04 Louisville, Kentucky, United States, 40202 United States, Minnesota Valeant Site 06 Fridley, Minnesota, United States, 55432 United States, North Carolina Valeant Site 02 High Point, North Carolina, United States, 27262 United States, Texas Valeant Site 01 Houston, Texas, United States, 77065 收起 <<
NCT01610596	-		Completed	-	-
NCT02123966	-		Terminated(Due to slow accrual... 展开 >>, study team has decided to end the study early.) 收起 <<	-	-
NCT01870050	Lichen Simples Chronicus and P... 展开 >>rurigo 收起 <<	Not Applicable	Not yet recruiting	November 2019	United States, Illinois ... 展开 >> J H Stroger Hospital of Cook County Not yet recruiting Chicago, Illinois, United States, 60612 Contact: Joerg Albrecht, MD 312-864-4480 jalbrecht@cookcountyhhs.org Principal Investigator: Joerg Albrecht Sub-Investigator: Warren Piette, MD 收起 <<
NCT01313221	Psoriasis	Phase 3	Completed	-	Canada, Alberta ... 展开 >> Research Site Calgary, Alberta, Canada, T2G 1B1 Canada, British Columbia Research Site Surrey, British Columbia, Canada, V3R 6A7 Research Site Vancouver, British Columbia, Canada, V5Z 4E8 Canada, Manitoba Research Site Winnipeg, Manitoba, Canada, R3C 0N2 Canada, New Brunswick Research Site Moncton, New Brunswick, Canada, E1C 8X3 Canada, Newfoundland and Labrador Research Site St. John's, Newfoundland and Labrador, Canada, A1A 5E8 Research Site St. John's, Newfoundland and Labrador, Canada, A1C 2H5 Canada, Nova Scotia Research Site Halifax, Nova Scotia, Canada, B3H 1Z4 Canada, Ontario Research Site Courtice, Ontario, Canada, L1E 3C3 Research Site Markham, Ontario, Canada, L3P 1A8 Research Site Mississauga, Ontario, Canada, L5H 1G9 Research Site North Bay, Ontario, Canada, P1B 3Z7 Research Site Peterborough, Ontario, Canada, K9J 1Z2 Research Site Richmond Hill, Ontario, Canada, L4B 1A5 Research Site Sudbury, Ontario, Canada, P3C 1X8 Research Site Toronto, Ontario, Canada, M3H 5Y8 Research Site Toronto, Ontario, Canada, M4V 1R1 Research Site Waterloo, Ontario, Canada, N2J 1C4 Research Site Windsor, Ontario, Canada, N8W 5L7 Canada, Quebec Research Site Montreal, Quebec, Canada, H2K 4L5 Research Site Montreal, Quebec, Canada, H3Z 2S6 Research Site Saint-Hyacinthe, Quebec, Canada, J2S 6L6 Canada Research Site Quebec, Canada, G1J 1X7 Research Site Quebec, Canada, G1V 4X7 收起 <<
NCT03089775	Contact Dermatitis	Phase 1	Completed	-	Canada, Quebec ... 展开 >> Innovaderm Research Inc. Montreal, Quebec, Canada, H2K 4L5 收起 <<
NCT03758365	Vasoconstriction	Phase 1	Recruiting	January 15, 2019	France ... 展开 >> CPCAD Recruiting Nice, France, 06200 Contact: Catherine Queille-Roussel, MD 收起 <<
NCT03399526	Psoriasis	Phase 1	Completed	-	Germany ... 展开 >> Hamburg, Germany, 20095 收起 <<
NCT00457288	Cutaneous Mastocytosis	Phase 2	Completed	-	Germany ... 展开 >> Klinik und Poliklinik für Dermatologie und Venerologie der Universität Köln, Germany, D-50924 Universitäts-Hautklinik Mainz, Germany, D-55131 Klinik und Poliklinik für Dermatologie und Allergologie der LMU München, Germany, D-80337 Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein der TU München, Germany, D-80802 收起 <<
NCT01313221	-		Completed	-	-
NCT02355639	Skin and Connective Tissue Dis... 展开 >>eases 收起 <<	Phase 1	Completed	-	Germany ... 展开 >> Charité - Universitaetsmedizin Berlin, Department of Dermatology and Allergy Berlin, Germany, 10117 收起 <<
NCT02940002	Psoriasis	Phase 1	Completed	-	Germany ... 展开 >> Schwerin, Mecklenburg-Vorpommern, Germany, 19055 Bochum, Nordrhein-Westfalen, Germany, 44803 Hamburg, Germany, 20095 收起 <<
NCT01946386	Psoriasis Vulgaris	Phase 1	Completed	-	France ... 展开 >> CPCAD, Centre de Pharmacologie Clinique Appliquée à la Dermatologie Nice, France, 06202 收起 <<
NCT02445807	Chronic Stable Plaque Psoriasi... 展开 >>s 收起 <<	Phase 3	Completed	-	-
NCT02392130	Skin Tissue Diseases ... 展开 >> Connective Tissue Diseases 收起 <<	Phase 1	Completed	-	Germany ... 展开 >> bioskin GmbH Hamburg, Germany, 20095 收起 <<
NCT02635204	-		Completed	-	-
NCT02376049	Atopic Dermatitis	Phase 1	Completed	-	Canada, Quebec ... 展开 >> Innovaderm Research Inc. Montreal, Quebec, Canada, H2K 4L5 Israel Beit Harofim Netanya, Israel, 42701 收起 <<
NCT03584360	Psoriasis Vulgaris	Phase 2	Not yet recruiting	June 2019	-
NCT02635204	Psoriasis	Phase 3	Completed	-	-
NCT02973776	Psoriasis Vulgaris	Phase 1	Completed	-	France ... 展开 >> CPCAD Nice, Cedex, France, 06202 收起 <<
NCT02487212	Hypertrophic Scars	Phase 4	Completed	-	Thailand ... 展开 >> Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 收起 <<
NCT00769184	-		Completed	-	-
NCT02445807	-		Completed	-	-
NCT02492373	Lentigines Po... 展开 >>st Inflammatory Hyperpigmentation 收起 <<	Not Applicable	Completed	-	Thailand ... 展开 >> Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 收起 <<
NCT00769184	Psoriasis	Not Applicable	Completed	-	United States, New Jersey ... 展开 >> Windsor Dermatology East Windsor, New Jersey, United States, 08520 收起 <<
NCT03535233	Alopecia Areata	Phase 4	Completed	-	-
NCT00779792	Dermatitis, Contact ... 展开 >> Dermatitis, Occupational 收起 <<	Phase 4	Unknown	November 2008	Denmark ... 展开 >> Department of Dermatology, Odense University Hospital Odense, Denmark, 5000 收起 <<
NCT02680717	Scleroderma	Phase 1	Withdrawn(Unable to obtain IRB... 展开 >> approval at all sites) 收起 <<	May 2017	-
NCT01987076	Drug Rash With Eosinophilia an... 展开 >>d Systemic Symptoms 收起 <<	Not Applicable	Unknown	October 2016	France ... 展开 >> Henri Mondor Hospital Recruiting Creteil, France, 94010 Contact: Olivier CHOSIDOW, MD, PhD (0)149812501 ext +33 olivier.chosidow@hmn.aphp.fr Contact: Laetitia GREGOIRE, M.Sc (0)149814164 ext +33 laetitia.gregoire@hmn.aphp.fr Principal Investigator: Olivier CHOSIDOW, MD, PhD 收起 <<
NCT02936492	Psoriasis	Phase 1	Terminated	-	Germany ... 展开 >> Hamburg, Germany, 20251 收起 <<
NCT01407471	Cutaneous Atrophy Due to Corti... 展开 >>costeroids 收起 <<	Phase 2	Completed	-	France ... 展开 >> Bichat Hospital Paris, France, 75877 收起 <<
NCT02313870	Bullous Pemphigoid	Phase 3	Unknown	December 2015	France ... 展开 >> University Hospital Of Montpellier Recruiting Montpellier, France, 34295 Contact: Olivier Dereure, MD, PhD 04 67 33 69 06 ext +33 o-dereure@chu-montpellier.fr Principal Investigator: Olivier Dereure, MD, PhD 收起 <<
NCT01381445	Dermatitis, Atopic	Phase 1	Completed	-	Germany ... 展开 >> GSK Investigational Site Berlin, Germany, 10117 收起 <<
NCT01591785	Hand Eczema F... 展开 >>oot Eczema 收起 <<	Not Applicable	Completed	-	United States, New York ... 展开 >> Mount Sinai School of Medicine New York, New York, United States, 10029 收起 <<
NCT00102557	Lichen Planus, Oral	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 收起 <<
NCT03386643	Oral Lichen Planus	Phase 2	Active, not recruiting	December 6, 2018	Brazil ... 展开 >> School of Dentistry of Ribeirão Preto, University of São Paulo Ribeirão Preto, São Paulo, Brazil, 14040-904 收起 <<
NCT00655512	Healthy	Phase 1	Completed	-	Germany ... 展开 >> Department of Dermatology, Medical Faculty, TU Dresden Dresden, Germany 收起 <<
NCT03286582	Bullous Pemphigoid	Phase 2	Recruiting	May 2019	Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Chia-Yu Chu, Dr. 收起 <<
NCT02733874	Psoriasis	Phase 4	Completed	-	-
NCT02368886	Colon Adenocarcinoma ... 展开 >> Rectal Adenocarcinoma Stage III Colorectal Cancer AJCC v7 Stage IIIA Colorectal Cancer AJCC v7 Stage IIIB Colorectal Cancer AJCC v7 Stage IIIC Colorectal Cancer AJCC v7 Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 收起 <<	Phase 2	Active, not recruiting	June 22, 2019	-
NCT01400022	Vulvar Lichen Sclerosus	Not Applicable	Completed	-	Germany ... 展开 >> Department of Dermatology, Ruhr University Bochum Bochum, NRW, Germany, 44791 收起 <<
NCT01235442	Psoriasis	Phase 3	Completed	-	-
NCT01235442	-		Completed	-	-
NCT00470392	Psoriasis	Not Applicable	Terminated(Recruiting complete... 展开 >> and administrative termination) 收起 <<	-	United States, Ohio ... 展开 >> University Hospital Case Medical Center Cleveland, Ohio, United States, 44106 VA Medical Center, Cleveland Cleveland, Ohio, United States, 44106 收起 <<
NCT01043224	Psoriasis Vulgaris	Phase 1	Completed	-	France ... 展开 >> LEO Pharma site Nice, France, 06202 收起 <<
NCT03320460	Lichen Planus, Oral ... 展开 >> Low-Level Light Therapy 收起 <<	Not Applicable	Not yet recruiting	December 2020	-
NCT00438399	Scalp Psoriasis	Phase 3	Completed	-	Italy ... 展开 >> Clinica Dermatologica Azienda Ospedaliera Policlinico di Modena Modena, Italy, 41100 收起 <<
NCT00438399	-		Completed	-	-
NCT00715975	Psoriasis	Phase 2 Phase 3	Completed	-	Brazil ... 展开 >> Lal Clinica Valinhos, Sao Paulo, Brazil, 13270000 收起 <<
NCT02360202	Bullous Pemphigoid	Phase 4	Recruiting	December 2017	France ... 展开 >> Rouen University Hospital Recruiting Rouen, France, 76031 Contact: Sophie Duvert Lehembre, MD 收起 <<
NCT01453686	Alopecia Areata	Phase 3	Completed	-	Canada, Ontario ... 展开 >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 收起 <<
NCT00862654	Scalp Seborrheic Dermatitis	Phase 3	Completed	-	Belgium ... 展开 >> Galderma Investigational Center Brugge, Belgium Galderma Investigational Center Bruxelles, Belgium Galderma Investigational Center Geel, Belgium Galderma Investigational Center Gent, Belgium Galderma Investigational Center Liege, Belgium Galderma Investigational Center Mons, Belgium France Galderma Investigational Center Paris, France Germany Galderma Investigational Center Berlin, Germany Galderma Investigational Center Bonn, Germany Galderma Investigational Center Hamburg, Germany Galderma Investigational Center Lubeck, Germany Galderma Investigational Center Mahlow, Germany Galderma Investigational Center Wuppertal, Germany Korea, Republic of Galderma Investigational Center Seoul, Korea, Republic of Mexico Galderma Investigational Center Guadalajara, Mexico Galderma Investigational Center Mexico, Mexico Galderma Investigational Center Naucalpan, Mexico Galderma Investigational Center Zapopan, Jalisco, Mexico 收起 <<
NCT03592342	Oral Lichen Planus	Phase 2	Recruiting	March 31, 2019	United States, Massachusetts ... 展开 >> Tufts University, School of Dental Medicine Recruiting Boston, Massachusetts, United States, 02111 Contact: Athena Papas, DMD 617-636-3931 Athena.Papas@tufts.edu Brigham and Women's Hospital, Division of Oral Medicine and Dentistry Recruiting Boston, Massachusetts, United States, 02115 Contact: Vidya Sankar, DMD, MHS 617-525-8412 vsankar@bwh.harvard.edu United States, New York NYU College of Dentistry, Bluestone Center for Clinical Research Recruiting New York, New York, United States, 10010 Contact: Alexander R Kerr, DDS, MSD 347-721-7506 ark3@nyu.edu United States, North Carolina UNC Dermatology and Skin Cancer Center Recruiting Chapel Hill, North Carolina, United States, 27516 Contact: Donna Aline Culton, MD +1 984 974 3669 donna_culton@med.unc.edu Contact: Natasha Marvi, Study Coordinator +1 984 974 3670 natasha_marvi@med.unc.edu Carolinas Center for Oral Health Recruiting Charlotte, North Carolina, United States, 28209 Contact: Joul J Napenas, DDS 704-512-2110 joel.napenas@atriumhealth.org Wake Forest University, Health Sciences Dept. of Dermatology Recruiting Winston-Salem, North Carolina, United States, 27104 Contact: William Huang, MD, MPH 336-716-3775 whuang@wakehealth.edu United States, Pennsylvania University of Pennsylvania Health System, Dept. Oral amd Maxillofacial Surgery Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Thomas P Sollecito, DMD 215-898-6627 tps@upenn.edu United States, Texas Texas A&M University (TAMU), College of Dentistry Not yet recruiting Dallas, Texas, United States, 75246 Contact: Paras B Patel, DDS 214-828-8116 ppatel10@tamhsc.edu UT Southwestern Medical Center Department of Surgery Not yet recruiting Dallas, Texas, United States, 75390-9109 Contact: Thomas Schlieve, DDS, MD 214-648-3034 Thomas.Schlieve@UTSouthwestern.edu Canada, Alberta Kaye Edmonton Clinic Not yet recruiting Edmonton, Alberta, Canada, T6G1Z1 Contact: Tim McGraw, D.D.S +1-780 492-5195 wmcgaw@ualberta.ca Contact: Breanne Stewart, Coordinator +1-780-974-8606 breanne1@ualberta.ca Canada, Ontario Health Sciences North, North East Cancer Center Recruiting Sudbury, Ontario, Canada, P3E5JL Contact: Debbie Saunders, D.D.S +1-705 523-7334 dsaunders@hsnsudbury.ca Contact: Pamela Leduc, Coordinator +1-705-523-7300 ext 1923 Denmark Rigshospitalet Recruiting Copenhagen, Denmark, 2100 Contact: Morten Schiødt, DDS, Dr +45 3545 1880 morten.schioedt@regionh.dk Germany Universitätsklinikum Bonn (AöR), Klinik und Poliklinik für Dermatologie und Allergologie Recruiting Bonn, Germany, 53127 Contact: Thomas Bieber, Prof Dr Med +49 (0)228 287 16811 Thomas.Bieber@ukb.uni-bonn.de LMU München, Klinik und Poliklinik für Dermatologie und Allergologie Recruiting Munich, Germany, 80337 Contact: Thomas Ruzicka, Prof Dr Med +49 (0)89 44005 60051 Thomas.Ruzicka@med.uni-muenchen.de Ireland Cork University Dental School and Hospital Not yet recruiting Cork, Ireland, T12 E8YV Contact: Christine McCreary, Dr +353 (0)21 4901105 C.McCreary@ucc.ie Dublin Dental University and Hospital Trinity College Dublin Not yet recruiting Dublin, Ireland, D02 F589 Contact: Claire Healy, Dr + 353 1 612 7314 claire.healy@dental.tcd.ie United Kingdom Leeds Dental Institute Not yet recruiting Leeds, United Kingdom, LS9 9LU Contact: Alan Mighell, Dr +44 (0)113 343 6121 A.J.Mighell@leeds.ac.uk King´s College London Dental Institute, Oral Clinical Research Unit Recruiting London, United Kingdom, SE1 9RT Contact: Richard Cook, Dr +44 (0)20 78485958 richard_james.cook@kcl.ac.uk University College London and University College London Hospitals Trust Recruiting London, United Kingdom, WC1X 8LD Contact: Stefano Fedele, Dr +44 (0)20 3456 1004 s.fedele@ucl.ac.uk University of Sheffield, School of Clinical Dentistry Recruiting Sheffield, United Kingdom, S10 2TA Contact: Anne Hegarty, Dr +44 (0)114 2268669 anne.hegarty@sth.nhs.uk 收起 <<
NCT00297011	Herpes Labialis	Phase 2	Completed	-	United States, Utah ... 展开 >> University of Utah Salt Lake City, Utah, United States, 84132 收起 <<
NCT00470392	-		Terminated(Recruiting complete... 展开 >> and administrative termination) 收起 <<	-	-
NCT00862654	-		Completed	-	-
NCT00393263	Lichen Sclerosus	Phase 2	Completed	-	United States, District of Col... 展开 >>umbia Center for VulvoVaginal Disorders Washington, District of Columbia, United States, 21012 收起 <<
NCT02416531	Vulvar Lichen Sclerosus	Not Applicable	Completed	-	Brazil ... 展开 >> Hospital Pérola Byington São Paulo, SP, Brazil, 01314000 收起 <<
NCT01126255	Vulvar Lichen Sclerosus	Phase 2	Terminated(Recruitment problem... 展开 >>s) 收起 <<	-	Switzerland ... 展开 >> Dep. of Obstetrics and Gynecology, Bern University Hospital Bern, Switzerland, 3010 收起 <<
NCT00400725	Scalp Psoriasis	Phase 3	Completed	-	Canada ... 展开 >> centre de Recherche Dermatologique du Québec Quebec, Canada 收起 <<
NCT01323673	-		Completed	-	-
NCT00437255	Plaque Psoriasis	Phase 4	Completed	-	United States, Minnesota ... 展开 >> Minnesota Clinical Study Center Fridley, Minnesota, United States, 55432 United States, Texas DermResearch, Inc. Austin, Texas, United States, 78759 J & S Studies, Inc. Bryan, Texas, United States, 77802 Baylor Research Institute Dallas, Texas, United States, 75230 收起 <<
NCT00803439	-		Completed	-	-
NCT01205880	Psoriasis	Phase 4	Completed	-	United States, New York ... 展开 >> Mount Sinai School of Medicine New York, New York, United States, 10029 收起 <<
NCT01323673	Dermatitis, Chronic	Phase 4	Completed	-	United States, California ... 展开 >> GSK Investigational Site San Diego, California, United States, 92123 United States, Florida GSK Investigational Site Boynton Beach, Florida, United States, 33437 GSK Investigational Site West Palm Beach, Florida, United States, 33401 United States, Kentucky GSK Investigational Site Louisville, Kentucky, United States, 40202 GSK Investigational Site Louisville, Kentucky, United States, 40217 United States, New Jersey GSK Investigational Site Belleville, New Jersey, United States, 07109 GSK Investigational Site Montclair, New Jersey, United States, 07042 United States, Tennessee GSK Investigational Site Knoxville, Tennessee, United States, 37922 GSK Investigational Site Nashville, Tennessee, United States, 37215 United States, Texas GSK Investigational Site Austin, Texas, United States, 78759 收起 <<
NCT03026478	Oral Lichen Planus	Phase 2	Recruiting	June 2018	India ... 展开 >> Komali Garlapati Recruiting Hyderabad, Telangana, India, 500060 Contact: KOMALI GARLAPATI, M.D.S. +918008884945 komali_garlapati@yahoo.co.in 收起 <<
NCT00437216	-		Completed	-	United States, New Jersey ... 展开 >> DHC Dimensional HealthCare, Inc. (Clinical Research Organization) Cedar Knolls, New Jersey, United States, 76117 收起 <<
NCT01012713	-		Completed	-	-
NCT00757874	Vulvar Lichen Sclerosus	Phase 2	Completed	-	Canada, Quebec ... 展开 >> CHU Sainte-Justine Montreal, Quebec, Canada, H3P 3N5 收起 <<
NCT02744378	Oral Lichen Planus	Phase 2	Completed	-	-
NCT01012713	Chronic Stable Plaque Psoriasi... 展开 >>s 收起 <<	Phase 4	Completed	-	United States, California ... 展开 >> UCSF Psoriasis and Skin Treatment Center San Francisco, California, United States, 94118 收起 <<
NCT00436540	Psoriasis	Phase 4	Completed	-	United States, California ... 展开 >> Solano Clinical Research Vallejo, California, United States, 94589 United States, Missouri Central Dermatology, PC St. Louis, Missouri, United States, 63117 收起 <<
NCT03453190	Psoriasis	Phase 4	Recruiting	June 30, 2020	United States, Maryland ... 展开 >> Washington Dermatology Center Recruiting Rockville, Maryland, United States, 20852 Contact: Vicki Smith 301-984-3000 wdcderm22@gmail.com Contact: Ronald Prussick, M.D. 3019843000 drprussick@aol.com Principal Investigator: Ronald Prussick, MD 收起 <<
NCT00658788	Psoriasis	Phase 3	Completed	-	United States, California ... 展开 >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Georgia MedaPhase, Inc. Newnan, Georgia, United States, 30263 Gwinnett Clinical Research Center, Inc Snellville, Georgia, United States, 30078 United States, Indiana Hudson Dermatology Evansville, Indiana, United States, 47714 United States, New York Mount Sinai Department of Dermatology New York, New York, United States, 10029 United States, Ohio Northeastern Ohio Universities College of Medicine Warren, Ohio, United States, 44483 United States, Oklahoma Central Sooner Research Norman, Oklahoma, United States, 73069 United States, Texas J&J Studies, Inc College Station, Texas, United States, 77840 Suzanne Bruce and Associates, PA Houston, Texas, United States, 75390 United States, Virginia Virginia Clinical Research, Inc Norfolk, Virginia, United States, 23507 United States, Washington Dermatology Associates of Seattle, PLLC Seattle, Washington, United States, 98101 United States, Wisconsin Madison Skin and Research, Inc Madison, Wisconsin, United States, 53719 收起 <<
NCT02131324	-		Completed	-	-
NCT01111981	Alopecia	Phase 4	Unknown	October 2010	United States, Maryland ... 展开 >> Callender Center for Clinical Research Recruiting Mitchellville, Maryland, United States, 20721 Contact: Lynn Carter, BA 301-249-0970 clinresearch@callenderskin.com Contact: Niccole Mathews 301-249-0970 clinresearch@callenderskin.com 收起 <<
NCT01699412	Graft vs Host Disease ... 展开 >> Oral Manifestations 收起 <<	Phase 3	Completed	-	Brazil ... 展开 >> Hematology and Hemotherapy Center Campinas, São Paulo, Brazil, 13083-878 Clementino Fraga Filho University Hospital Rio de Janeiro, Brazil, 21941-913 收起 <<
NCT00881868	Scalp Psoriasis	Phase 4	Completed	-	United States, California ... 展开 >> Dermatology Research Associates Los Angeles, California, United States, 90045 United States, Indiana Hudson Dermatology Evansville, Indiana, United States, 47714 United States, New York Research Division of The Skin Specialty Group New York, New York, United States, 10155 United States, Washington Dermatology Associates, PLLC Seattle, Washington, United States, 98101 收起 <<
NCT00881868	-		Completed	-	-
NCT00828464	Hand Dermatosis	Phase 4	Completed	-	United States, Kentucky ... 展开 >> Physicians Skin Care Louisville, Kentucky, United States, 40217 收起 <<
NCT00828464	-		Completed	-	-
NCT00864500	Healthy	Phase 1	Completed	-	United States, Texas ... 展开 >> Novum Pharmaceutical Research Services Houston, Texas, United States, 77042-4712 收起 <<
NCT00658788	-		Completed	-	-
NCT00852761	-		Completed	-	-
NCT00864240	Healthy	Phase 1	Completed	-	United States, Texas ... 展开 >> Novum Pharmaceutical Research Services Houston, Texas, United States, 77042-4712 收起 <<
NCT02131324	Psoriasis	Phase 2	Completed	-	United States, Arizona ... 展开 >> Advanced Research Associates Glendale, Arizona, United States, 85308 Agave Clinical Research, LLC Mesa, Arizona, United States, 85202 United States, California T. Joseph Raoof, MD, Inc. Encino, California, United States, 91436 United States, Florida International Dermatology Research, Inc. Miami, Florida, United States, 33144 FXM Research Corp. Miami, Florida, United States, 33175 FXM Research Miramar Miramar, Florida, United States, 33027 Belleair Research Pinellas Park, Florida, United States, 33781 Forward Clinical Trials Tampa, Florida, United States, 33624 United States, Georgia Marietta Dermatology Clinical Research, Inc. Marietta, Georgia, United States, 30060 United States, Kentucky Determatology Specialists Research, LLC Louisville, Kentucky, United States, 40202 United States, Nebraska Quality Clinical Research, Inc. Omaha, Nebraska, United States, 68114 United States, North Carolina Dermatology Consulting Services High Point, North Carolina, United States, 27262 United States, Oklahoma Lynn Health Science Institute Oklahoma City, Oklahoma, United States, 73112 United States, Rhode Island Clinical Partners, LLC Johnston, Rhode Island, United States, 02919 United States, South Carolina Radiant Research, Inc. Greer, South Carolina, United States, 29650 收起 <<
NCT01893567	Plaque Psoriasis	Phase 4	Completed	-	United States, Michigan ... 展开 >> Hamzavi Dermatology Fort Gratiot, Michigan, United States, 48059 收起 <<
NCT01557517	Oral Chronic Graft vs Host Dis... 展开 >>ease 收起 <<	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00852761	Plaque-Type Psoriasis	Phase 4	Completed	-	United States, North Carolina ... 展开 >> Wake Forest University Health Sciences Department of Dermatology Winston-Salem, North Carolina, United States, 27157 收起 <<
NCT01893567	-		Completed	-	-
NCT01745133	Psoriasis	Phase 4	Completed	-	United States, Kentucky ... 展开 >> DermResearch, PLLC Louisville, Kentucky, United States, 40217 收起 <<
NCT02319616	Toxic Epidermal Necrolysis	Phase 1 Phase 2	Active, not recruiting	July 2019	United States, California ... 展开 >> University of California, Davis Department of Dermatology Sacramento, California, United States, 95816 收起 <<
NCT01745133	-		Completed	-	-
NCT00988637	Plaque Psoriasis	Phase 4	Completed	-	United States, California ... 展开 >> Dermatology Research Associates Los Angeles, California, United States, 90045 Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Indiana Hudson Dermatology Evansville, Indiana, United States, 47714 United States, Minnesota Minnesota Clinical Study Center Fridley, Minnesota, United States, 55432 United States, Texas Baylor Research Institute Dermatology Research Dallas, Texas, United States, 75246 Canada, Ontario Probity Medical Research Waterloo, Ontario, Canada, N2J1C4 收起 <<
NCT00733954	Plaque Psoriasis	Phase 4	Completed	-	United States, California ... 展开 >> East Bay Dermatology Medical Group, Inc. Fremont, California, United States, 94538 Solano Clinical Research Vallejo, California, United States, 94589 United States, Michigan Henry Ford Medical Center Detroit, Michigan, United States, 48202 United States, Minnesota Minnesota Clinical Study Center Fridley, Minnesota, United States, 55432 United States, New York Dermatology Associates of Rochester Rochester, New York, United States, 14623 United States, Texas Baylor Research Institute - Dermatology Research Dallas, Texas, United States, 75246 收起 <<
NCT00842153	Psoriasis	Phase 4	Completed	-	United States, California ... 展开 >> Center for Dermatology, Cosmetic and Laser Fremont, California, United States, 94538 United States, Kentucky Dermatology Specialists Louisville, Kentucky, United States, 40202 收起 <<
NCT00842153	-		Completed	-	-
NCT01703325	Psoriatic Nails	Phase 4	Completed	-	Thailand ... 展开 >> Siriraj Hospital Bangkok, Thailand, 10700 收起 <<
NCT00733954	-		Completed	-	-
NCT00988637	-		Completed	-	-
NCT02573883	Vulvar Lichen Sclerosus	Phase 3	Recruiting	September 2019	United States, District of Col... 展开 >>umbia Medstar Washington Hospital Center Lafayette Office Recruiting Washington, District of Columbia, United States, 20010 Contact: Cheryl B Iglesia, MD 202-877-6526 Cheryl.Iglesia@medstar.net Contact: Patricia Tanjutco (202)877-6526 Joanna.l.peterson@medstar.net Sub-Investigator: Linda S Burkett, MD Sub-Investigator: Andrew I Sokol, MD Sub-Investigator: Amy J Park, MD Sub-Investigator: Robert E Gutman, MD Sub-Investigator: Lee A Richter, MD 收起 <<

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